Protein Alignment ppk30 and Asic5

DIOPT Version :10

• Sequence 1: NP_651706.1
• Gene: ppk30 / 43487
• FlyBaseID: FBgn0039677
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: NP_071563.1
• Gene: Asic5 / 63866
• RGDID: 69295
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 527
• Identity: 107/527 - (20%)
• Similarity: 182/527 - (34%)
• Gaps: 174/527 - (33%)

  Fly     7 KPEPSSEDNDD-DH--------------KESKKKLKKEGAGGWASTRRYARIPLKIMAALATVYV 56
            :|.||..|... ||              .:::.|::|.   .|.|.         ::.:::.:..
  Rat    26 RPLPSPTDRKKFDHDFAISTSFHGIHNIAQNQNKVRKV---IWLSV---------VLGSVSLLVW 78

  Fly    57 SILSS-ERYFYYWVQTSIERTDMHVSEIDFPAVTIIPINLSILKAEKLSK------AYNLVQSVV 114
            .|.|. ..||.:...||||  ..:|.:|:|||||.  .||:..:.|.:|:      .:::|..|:
  Rat    79 QIYSRLVNYFMWPTTTSIE--VQYVEKIEFPAVTF--CNLNRFQTEAVSRFGIIFFLWDIVSKVL 139

  Fly   115 WQTPMSARLT-----------DENF--TEFSELENWNAQSWGIY--QALQMNCQHFFTECQWRRK 164
            ....:|...|           ..||  |||       .::.|.|  ....::|:.|...|..:.
  Rat   140 RLQEISGNNTGSPEALDFVASHRNFSITEF-------VKNNGFYLNHDTLVHCEFFGKTCDPKD- 196

  Fly   165 AMNCCDLFRPTKTFNGFAFEFN--------SLVS-SGRDETWPWSVASCGSYSGLNVKIKRQQGL 220
                   |:...|..|..|.||        :.|| |||               ||.:.:...|..
  Rat   197 -------FKHVFTEYGNCFTFNYGENVQSKNKVSVSGR---------------GLKLLLDVHQEE 239

  Fly   221 YTLNTM------GVI--VHEPTQL-----LGMSIDYSSEDRIVVPVEPLHFTAELDVRARPVQMR 272
            :|.|.:      |||  :|.|.:.     ||:|             .|:...|.:.:|    |::
  Rat   240 FTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLS-------------SPVGMHARVTIR----QLK 287

  Fly   273 RCYFENEIPTGKSRSECIYKCHVNYIISKCNCSLELPVKATQDEDNIAAAKESNGRRICGVKDLA 337
            ..:  .|.|.|:...:...:....|  |...|..|...|..|              |:||
  Rat   288 TIH--QEYPWGECNPDIKLRNFTTY--STYGCLKECKAKHIQ--------------RLCG----- 329

  Fly   338 CF------NQHRLSLFSMSNIIEESRDNV-------FSTVDCGCFPQCGHTQYHT----STY--- 382
            |.      |.....|....|.:....|::       ..|.:..|...|..|:|..    ||:
  Rat   330 CLPFLLPGNGVECDLLKYYNCVSPILDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYSTFPSQ 394

  Fly   383 --TEKMSAHTNLAA------AIEIDVYFQEETLFSYRSMLRFTLIDLMVSYGGIAGLIMGISVLG 439
              |:.::...|.:.      .:.|::.:.:......:.....::.:|:...||..||..|.|::.
  Rat   395 RATKFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLIT 459

  Fly   440 CINELLD 446
            .| |:::
  Rat   460 II-EIIE 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk30	NP_651706.1	ASC	47..446	CDD:459966	97/470 (21%)
Asic5	NP_071563.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000269|PubMed:27679529	1..30		1/3 (33%)
		ASC	41..466	CDD:459966	101/512 (20%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)