Protein Alignment ppk30 and SCNN1B

DIOPT Version :10

• Sequence 1: NP_651706.1
• Gene: ppk30 / 43487
• FlyBaseID: FBgn0039677
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 100/512 - (19%)
• Similarity: 165/512 - (32%)
• Gaps: 213/512 - (41%)

  Fly    83 IDFPAVTII---PINLSILK------------------AEKLSKA---YNLVQSVVWQTP----- 118
            :|||||||.   |...|.:|                  |.:||.|   .||..|:...||
Human   109 MDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLID 173

  Fly   119 ------------------------------------MSARL--------TDENFTEFSE-LENWN 138
                                                |:.||        |..|||..:: |..|.
Human   174 ERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWY 238

  Fly   139 -AQSWGIY------QALQMN---------CQHFFTECQWRRKAMNCCDLFRP----TKTFN---- 179
             .|:..|:      :.::|:         |......|.:|    |...:|.|    ...||
Human   239 ILQATNIFAQVPQQELVEMSYPGEQMILACLFGAEPCNYR----NFTSIFYPHYGNCYIFNWGMT 299

  Fly   180 ---------GFAFEFNSLVSSGRDETWPWSVASCG---------SYSGLNVKIKRQQGLYTLN-- 224
                     |..|....::..|:::..|:..::.|         ||..:     |.:|:|.::
Human   300 EKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFI-----RDEGIYAMSGT 359

  Fly   225 --TMGVIVHEPTQLLGMSIDYSSEDRIVVPVEPLHFTAELDVRARPVQMRRCYFENEIPTGKSRS 287
              ::||:| :..|.:|......:.:...|||:                    .|.::..|..|..
Human   360 ETSIGVLV-DKLQRMGEPYSPCTVNGSEVPVQ--------------------NFYSDYNTTYSIQ 403

  Fly   288 ECIYKCHVNYIISKCNCS---LELPVKATQDEDNIAAAKESNGRRICGVKDLA----CFNQHRLS 345
            .|:..|..:::|..|||.   ..||                .|.:.|..:|..    |::..::|
Human   404 ACLRSCFQDHMIRNCNCGHYLYPLP----------------RGEKYCNNRDFPDWAHCYSDLQMS 452

  Fly   346 LFSMSNIIEESRDNVFSTVDCGCFPQCGHTQY-------------------HTSTYTEKMSAHTN 391
            :......|..            |...|..|||                   |..:.....|.:..
Human   453 VAQRETCIGM------------CKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNIT 505

  Fly   392 LA--AAIEIDVYFQEETLFSYRSM---LRFTLIDLMVSYGGIAGLIMGISVLGCINE 443
            |:  ..:::::||||   |:||::   ....::.|:.:.||..|..||.||| |:.|
Human   506 LSRKGIVKLNIYFQE---FNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVL-CLIE 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk30	NP_651706.1	ASC	47..446	CDD:459966	100/512 (20%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	100/512 (20%)