DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk30 and ASIC1

DIOPT Version :9

Sequence 1:	NP_001263076.1	Gene:	ppk30 / 43487	FlyBaseID:	FBgn0039677	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_064423.2	Gene:	ASIC1 / 41	HGNCID:	100	Length:	574	Species:	Homo sapiens

Alignment Length:	495	Identity:	101/495 - (20%)
Similarity:	178/495 - (35%)	Gaps:	148/495 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GWASTRRYARIPLK-------IMAALATVYVSILSSER---YFYYWVQTSIERTDMHVSEIDFPA 87
            |.|....|.|:.||       .:.:||.:.  .:.:||   ||:|...|.::  ::..|::.|||
Human    29 GLAHIFSYERLSLKRALWALCFLGSLAVLL--CVCTERVQYYFHYHHVTKLD--EVAASQLTFPA 89

  Fly    88 VTIIPINLSILKAEKLSK--AYNLVQSVV-----WQTPMSARLTDE----------NFTEFSELE 135
            ||:  .||:..:..::||  .|:..:.:.     ::.| ..::.||          ||..|.. :
Human    90 VTL--CNLNEFRFSQVSKNDLYHAGELLALLNNRYEIP-DTQMADEKQLEILQDKANFRSFKP-K 150

  Fly   136 NWNAQSWGIYQALQMNCQHFFTECQWRRKAMNCCDLFRPTKTFNGFAFEFNSLVSSGRDETWPWS 200
            .:|.:.:  |.....:.:.....|.:|.:..:..| |:...|..|..:.||    ||||......
Human   151 PFNMREF--YDRAGHDIRDMLLSCHFRGEVCSAED-FKVVFTRYGKCYTFN----SGRDGRPRLK 208

  Fly   201 VASCGSYSGLNVKIKRQQGLYTLNTMGVIVHEPTQLLGMSIDYSSEDRIVVPVEPLHFTAELDVR 265
            ....|:.:||.:.:..||..| |...|. ..|.:...|:.:...|:|      || .|..:|...
Human   209 TMKGGTGNGLEIMLDIQQDEY-LPVWGE-TDETSFEAGIKVQIHSQD------EP-PFIDQLGFG 264

  Fly   266 ARP--------VQMRRCYFENEIPTGK--------------SRSECIYKCHVNYIISKCNCSL-E 307
            ..|        .:.|..|......|.|              |.:.|...|...|::..|||.: .
Human   265 VAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVH 329

  Fly   308 LPVKA---TQDEDNIAAAKESNGRRICGVKDLACFNQHRLSLFSMSNIIEESRDNVFSTVDCGCF 369
            :|..|   |.::     .||             |.:.      ::..::|:.::.      |.|.
Human   330 MPGDAPYCTPEQ-----YKE-------------CADP------ALDFLVEKDQEY------CVCE 364

  Fly   370 PQCGHTQYHTSTYTEKMSAHTN---LAA------------AIEIDVYFQEETLFSYRSMLRFTLI 419
            ..|..|:|.......|:.:..:   ||.            .:.:|::|:         :|.:..|
Human   365 MPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFE---------VLNYETI 420

  Fly   420 DLMVSYGGIAGLIMGISVLGCINELLDR---FACCRIPHG 456
            :...:|          .:.|.:.|||..   |:|    ||
Human   421 EQKKAY----------EIAGLLGELLMTPVPFSC----HG 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk30	NP_001263076.1	ASC	47..446	CDD:279230	90/459 (20%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	101/495 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920