DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk30 and Asic2

DIOPT Version :9

Sequence 1:	NP_001263076.1	Gene:	ppk30 / 43487	FlyBaseID:	FBgn0039677	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_037024.2	Gene:	Asic2 / 25364	RGDID:	2017	Length:	563	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	105/498 - (21%)
Similarity:	168/498 - (33%)	Gaps:	123/498 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KESKKKLKKEG-----AGGWASTRRYARIPLKIMAALATVYVSILSSERYFYYWVQTSIERTDMH 79
            :.|..:.|..|     ||..|:...:.|..|.::|...::.:.:..|.....||:... ..|.:|
  Rat    58 RPSLSRTKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSLGLLLSWSSNRLLYWLSFP-SHTRVH 121

  Fly    80 ---VSEIDFPAVTIIPINLSILKAEKLSKAYNLVQSVVW---------QTPMSARLT--DE---- 126
               ..::.|||||:  .|.:.|:..:|||. :|..:..|         ..|:.:.|.  ||
  Rat   122 REWSRQLPFPAVTV--CNNNPLRFPRLSKG-DLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQ 183

  Fly   127 ------NFTEFSELENWNAQSWGIYQALQMNCQHFFTECQWRRKAM---NCCDLFRPTKTFNGFA 182
                  :|..|....::...|......|....:.....|::|.:..   |...:|    |..|..
  Rat   184 WFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVF----TKYGKC 244

  Fly   183 FEFNSLVSSGRDETWPWSVASCGSYSGLNVKIKRQQGLYTLNTMGVIVHEPTQLLGMSIDYSSED 247
            :.||    ||.|.....:....|:.:||.:.:..||..| |...|. ..|.|...|:.:...|:.
  Rat   245 YMFN----SGEDGKPLLTTVKGGTGNGLEIMLDIQQDEY-LPIWGE-TEETTFEAGVKVQIHSQS 303

  Fly   248 RIVVPVEPLHFTAELDVRARP--------VQMRRCYFENEIPTGKSRSE--------------CI 290
                  || .|..||.....|        .:.|..|...  |.|:.||.              |.
  Rat   304 ------EP-PFIQELGFGVAPGFQTFVATQEQRLTYLPP--PWGECRSSEMGLDFFPVYSITACR 359

  Fly   291 YKCHVNYIISKCNCSL-ELPVKATQDEDNIAAAKESNGRRICGVKDLACFNQHRLSLFSMSNIIE 354
            ..|...||:..|||.: .:|                      |........||:........::.
  Rat   360 IDCETRYIVENCNCRMVHMP----------------------GDAPFCTPEQHKECAEPALGLLA 402

  Fly   355 ESRDNVFSTVDCGCFPQCGHTQYHTSTYTEKMSAHTNLAAAIE----------------IDVYFQ 403
            |...|.     |.|...|..|:|:......|:.:.|: |..:|                :|::|:
  Rat   403 EKDSNY-----CLCRTPCNLTRYNKELSMVKIPSKTS-AKYLEKKFNKSEKYISENILVLDIFFE 461

  Fly   404 EETLFSYRSMLRFTLIDLMVSYGGIAGLIMGISVLGCINELLD 446
            .....:......:.:..|:...||..||.:|.|:| .|.||.|
  Rat   462 ALNYETIEQKKAYEVAALLGDIGGQMGLFIGASLL-TILELFD 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk30	NP_001263076.1	ASC	47..446	CDD:279230	96/464 (21%)
Asic2	NP_037024.2	ENaC	64..557	CDD:273304	104/492 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020