DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk30 and Asic4

DIOPT Version :9

Sequence 1:	NP_001263076.1	Gene:	ppk30 / 43487	FlyBaseID:	FBgn0039677	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	XP_036020902.1	Gene:	Asic4 / 241118	MGIID:	2652846	Length:	586	Species:	Mus musculus

Alignment Length:	535	Identity:	112/535 - (20%)
Similarity:	183/535 - (34%)	Gaps:	141/535 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DDDHKESKKKLKKE-----GAGGWASTRRYARIPLKIMAALATVY-------------------V 56
            ::|.|..:|:...|     .|.|.|:.|     .|...|:.:|::                   :
Mouse    13 EEDAKPKEKEAGDEQSLLGAAQGPAAPR-----DLATFASTSTLHGLGRACGPGPHGLRRTLWAL 72

  Fly    57 SILSSERYFYYWVQTSIER---TDMHVSEID---------FPAVTIIPINLSILKAEKLSKA--Y 107
            ::|:|...|.|.. .|:.|   |..|:..:|         |||||:  .|::..:...||.|  :
Mouse    73 ALLTSLAAFLYQA-ASLARGYLTRPHLVAMDPAAPAPVAGFPAVTL--CNINRFRHSALSDADIF 134

  Fly   108 NLVQSVVWQTPMSA---RLTDENFTEFSELENWNAQSWGIYQALQMNCQHFFTECQWRRKAMNCC 169
            :|. ::....|...   |.....:.|...::..|.....:...|: :|......|    .|.|
Mouse   135 HLA-NLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQLADMLK-SCNFSGHHC----SASN-- 191

  Fly   170 DLFRPTKTFNGFAFEFNSLVSSGRDETWPWSVASCGSYSGLNVKIKRQQGLY------TLNT--- 225
              |....|..|..:.||:...|    :.|......|  |||.:.:..||..|      |..|
Mouse   192 --FSVVYTRYGKCYTFNADPQS----SLPSRAGGMG--SGLEIMLDIQQEEYLPIWRETNETSFE 248

  Fly   226 --MGVIVH---EPTQL----LGMSIDYSS-----EDRIVVPVEPL-HFTAELDVRARPVQMRRCY 275
              :.|.:|   ||..:    .|:|..:.:     |.|:....:|. :..||.::|...:|....|
Mouse   249 AGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYSAY 313

  Fly   276 FENEIPTGKSRSECIYKCHVNYIISKCNCSL-ELPVKATQDEDNIAAAKESNGRR-ICGVKDLAC 338
                     |.|.|..:|....::.:|:|.: .:|....|.............|| .|.......
Mouse   314 ---------SVSACRLRCEKEAVLQRCHCRMVHMPGGHLQPVFGATLLSSRTSRRQRCMRTTCTR 369

  Fly   339 FNQHRLSLFSMS-------------NIIEESRDNVFSTV------DCGCFPQCGHTQYHTSTYTE 384
            ...|...|..||             ||..|..|:...::      .|.|...|..|:|.......
Mouse   370 IYTHERVLMCMSGYLHMGNETICPPNIYIECADHTLDSLGGGSEGPCFCPTPCNLTRYGKEISMV 434

  Fly   385 KMSAHTNLAAA------------------IEIDVYFQEETLFSYRSMLRFTLIDLMVSYGGIAGL 431
            |:   .|..:|                  :.:||:|:..|..:......:.|..|:...||..||
Mouse   435 KI---PNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQQAAYGLSALLGDLGGQMGL 496

  Fly   432 IMGISVLGCINELLD 446
            .:|.|:|..: |:||
Mouse   497 FIGASILTLL-EILD 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk30	NP_001263076.1	ASC	47..446	CDD:279230	101/497 (20%)
Asic4	XP_036020902.1	ASC	40..535	CDD:413546	105/508 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910