DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk30 and Scnn1a

DIOPT Version :10

Sequence 1:NP_651706.1 Gene:ppk30 / 43487 FlyBaseID:FBgn0039677 Length:457 Species:Drosophila melanogaster
Sequence 2:NP_035454.3 Gene:Scnn1a / 20276 MGIID:101782 Length:699 Species:Mus musculus


Alignment Length:526 Identity:96/526 - (18%)
Similarity:157/526 - (29%) Gaps:199/526 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 ERYFYYWVQTSIERTDMHVSEIDFPAVTIIPIN-------------LSILKAEKLSKAYNLVQSV 113
            |.||.|.|..:|   :::..::.|||||:..:|             |..:..:.|...|....|.
Mouse   132 EEYFSYPVSLNI---NLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTLFDLYKYNSSY 193

  Fly   114 VWQ-----------------------TP------MSARLTDENFTEFSELENWNAQ----SWGI- 144
            ..|                       ||      .|||      :..|.:.:.|.|    .|.| 
Mouse   194 TRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSAR------SASSSVRDNNPQVDRKDWKIG 252

  Fly   145 YQALQMN---CQH---------------------------------------FFTECQWRRKAMN 167
            :|....|   |.:                                       |...|::.:...|
Mouse   253 FQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPALEEEALGSFIFTCRFNQAPCN 317

  Fly   168 CCDLFRPTKTFNGFAFEFNSLVSSGRDETWPWSVASCGSYSGLNVKIKRQQG-----LYTLNTMG 227
            ..:..:......|..:.||:..:|..     |..:..|..:||::.::.:|.     |.|:....
Mouse   318 QANYSQFHHPMYGNCYTFNNKNNSNL-----WMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGAR 377

  Fly   228 VIVH---EPTQL------------------------LGMSIDYSSEDRIVVPVEPLHFTAELDVR 265
            |:||   ||..:                        ||.:....:|:...|||:.|:        
Mouse   378 VMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLY-------- 434

  Fly   266 ARPVQMRRCYFENEIPTGKSRSECIYKCHVNYIISKCNCSLELPVKATQDEDNIAAAKESNGRRI 330
                           |:..::..||:.|....:|.||.|:.....|....|......:.|.|  .
Mouse   435 ---------------PSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWG--Y 482

  Fly   331 CGVKDLACFNQHRLSLFSMSNIIEESRDNVFSTVDCGCFPQCGHTQYHTST-YT----------- 383
            |..|..|.|:...|..||.                  |...|..|.|..|. |:           
Mouse   483 CYYKLQAAFSLDSLGCFSK------------------CRKPCSVTNYKLSAGYSRWPSVKSQDWI 529

  Fly   384 -EKMSAHTNLA------AAIEIDVYFQEETLFSYRSMLRFTLIDLMVSYGGIAGLIMGISVLGCI 441
             |.:|...|..      ...:::::|:|....:.......|::.|:.:.|....|..|.|||..:
Mouse   530 FEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVV 594

  Fly   442 N--ELL 445
            .  ||:
Mouse   595 EMAELI 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk30NP_651706.1 ASC 47..446 CDD:459966 96/526 (18%)
Scnn1aNP_035454.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71
ENaC 79..676 CDD:273304 96/526 (18%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000305|PubMed:18650438 200..270 13/75 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..244 7/38 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..699
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P37088 669..673
Blue background indicates that the domain is not in the aligned region.

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