DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk30 and Asic3

DIOPT Version :9

Sequence 1:	NP_001263076.1	Gene:	ppk30 / 43487	FlyBaseID:	FBgn0039677	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	XP_006535700.1	Gene:	Asic3 / 171209	MGIID:	2159339	Length:	563	Species:	Mus musculus

Alignment Length:	525	Identity:	101/525 - (19%)
Similarity:	167/525 - (31%)	Gaps:	170/525 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GAGG-------WASTRRYARIPLKIMAALATVYVSILSSERYF-YYWVQTSIERTDMHVSEIDFP 86
            |.||       ||:.         ::.:||.....:....||: .:..:|:::..:.|  ::.||
Mouse    35 GPGGLTLRRGLWATA---------VLLSLAAFLYQVAERVRYYGEFHHKTTLDERESH--QLTFP 88

  Fly    87 AVTIIPIN----------------LSILKAEKLSKAYNLVQSVVWQTPMSARLTDENFTEFSELE 135
            |||:..||                .::|..:....|..|  ..:.|.|...........:.::|
Mouse    89 AVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYL--RALGQPPAPPGFMPSPTFDMAQL- 150

  Fly   136 NWNAQSWGIYQALQMNCQHFFTECQWRRKAMNCC--DLFRPTKTFNGFAFEFNSLVSSGRDETWP 198
                     |.....:.:....:|::|.:.   |  :.|....|..|..:.|||........|.|
Mouse   151 ---------YARAGHSLEDMLLDCRYRGQP---CGPENFTVIFTRMGQCYTFNSGAQGAELLTTP 203

  Fly   199 WSVASCGSYSGLNVKIKRQQGLY---------TLNTMGVIV-----HEPTQL--LGMSIDYSSED 247
                ..|:.:||.:.:..||..|         |...:|:.|     .||..:  ||.......:.
Mouse   204 ----KGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHGQEEPPAIDQLGFGAAPGHQT 264

  Fly   248 RIVVPVEPLHF---------TAELDVRARPVQMRRCYFENEIPTGKSRSE-------CIYKCHVN 296
            .:....:.|.|         ||.:|....|        |...|.|...|.       |...|...
Mouse   265 FVSCQQQQLSFLPPPWGDCNTASVDPDFDP--------EPSDPLGSPSSSPPYSLIGCRLACESR 321

  Fly   297 YIISKCNCSL-----ELPVKATQDEDNIAAAKESNGRRICGVKDLACFNQHRLSLFSMSNIIEES 356
            |:..||.|.:     ..||.:.|.                 .||.|.....:..|||:...|...
Mouse   322 YVARKCGCRMMHMPGNSPVCSPQQ-----------------YKDCASPALGKAHLFSLPVPIHSD 369

  Fly   357 RDN-------VFSTV----------DCGCFPQCGHTQY-----------------------HTST 381
            .|:       :|..:          .|.|...|..|:|                       .:.|
Mouse   370 IDHNPLGQVLLFLALRPADAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRSET 434

  Fly   382 Y-TEKMSAHTNLAAAIEIDVYFQEETLFSYRSMLRFTLIDLMVSYGGIAGLIMGISVLGCINELL 445
            | ||.:         :.:|::|:.....:......:.:.:|:...||..||.:|.|:| .|.|:|
Mouse   435 YITENV---------LVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLL-TILEIL 489

  Fly   446 DRFAC 450
            | :.|
Mouse   490 D-YLC 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk30	NP_001263076.1	ASC	47..446	CDD:279230	93/495 (19%)
Asic3	XP_006535700.1	ASC	21..546	CDD:383197	101/525 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920