DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk30 and Asic1

DIOPT Version :9

Sequence 1:	NP_001263076.1	Gene:	ppk30 / 43487	FlyBaseID:	FBgn0039677	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001276720.1	Gene:	Asic1 / 11419	MGIID:	1194915	Length:	559	Species:	Mus musculus

Alignment Length:	546	Identity:	103/546 - (18%)
Similarity:	181/546 - (33%)	Gaps:	171/546 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WKP-------EPSSEDNDDDHKESKKKLK--------------------------KEGAGG---- 33
            |.|       :.|||..:::.||.:..::                          .||..|
Mouse    25 WGPHHHHRQQQDSSESEEEEEKEKESGMELDEGDSPRDLVAFANSCTLHGASHVFVEGGPGPRQA 89

  Fly    34 -WASTRRYARIPLKIMAALATVYVSILSSERYFYYWVQTSIERTD-MHVSEIDFPAVTIIPINLS 96
             ||         :..:.||......:  .:|..||.....:...| :..:|:.|||||.  .|.:
Mouse    90 LWA---------VAFVIALGAFLCQV--GDRVAYYLSYPHVTLLDEVATTELVFPAVTF--CNTN 141

  Fly    97 ILKAEKLSKAYNLVQSVVWQTPMSARLTDENFTEFSEL-----ENWNAQSWGIYQALQMNC---Q 153
            .::..:||     ...:::..||..  .||:......|     |.::.:.:.:::....:|   :
Mouse   142 AVRLSQLS-----YPDLLYLAPMLG--LDESDDPGVPLAPPGPEAFSGEPFNLHRFYNRSCHRLE 199

  Fly   154 HFFTECQWRRKAMNC---C--DLFRPTKTFNGFAFEFNSLVSSGRDETWPWSVASCGSYSGLNVK 213
            .....|.:      |   |  ..|....|..|..:.||    ||:|..........|:.:||.:.
Mouse   200 DMLLYCSY------CGGPCGPHNFSVVFTRYGKCYTFN----SGQDGRPRLKTMKGGTGNGLEIM 254

  Fly   214 IKRQQGLYTLNTMGVIVHEPTQLLGMSIDYSSEDRIVVPVEPLHFTAELDVRARP--------VQ 270
            :..||..| |...|. ..|.:...|:.:...|:|      || .|..:|.....|        .:
Mouse   255 LDIQQDEY-LPVWGE-TDETSFEAGIKVQIHSQD------EP-PFIDQLGFGVAPGFQTFVSCQE 310

  Fly   271 MRRCYFENEIPTGK--------------SRSECIYKCHVNYIISKCNCSL-ELPVKA---TQDED 317
            .|..|..:  |.|.              |.:.|...|...|::..|||.: .:|..|   |.::
Mouse   311 QRLIYLPS--PWGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQ- 372

  Fly   318 NIAAAKESNGRRICGVKDLACFNQHRLSLFSMSNIIEESRDNVFSTVDCGCFPQCGHTQYHTSTY 382
                .||             |.:.      ::..::|:.::.      |.|...|..|:|.....
Mouse   373 ----YKE-------------CADP------ALDFLVEKDQEY------CVCEMPCNLTRYGKELS 408

  Fly   383 TEKMSAHTN---LAA------------AIEIDVYFQEETLFSYRSMLRFTLIDLMVSYGGIAGLI 432
            ..|:.:..:   ||.            .:.:|::|:.....:......:.:..|:...||..||.
Mouse   409 MVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLF 473

  Fly   433 MGISVLGCINELLD------RFACCR 452
            :|.|:| .:.||.|      :...||
Mouse   474 IGASIL-TVLELFDYAYEVIKHRLCR 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk30	NP_001263076.1	ASC	47..446	CDD:279230	88/453 (19%)
Asic1	NP_001276720.1	ASC	63..541	CDD:295594	96/508 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920