Protein Alignment ppk30 and Asic1

DIOPT Version :10

• Sequence 1: NP_651706.1
• Gene: ppk30 / 43487
• FlyBaseID: FBgn0039677
• Length: 457
• Species: Drosophila melanogaster
• Sequence 2: NP_001276720.1
• Gene: Asic1 / 11419
• MGIID: 1194915
• Length: 559
• Species: Mus musculus
• Alignment Length: 546
• Identity: 103/546 - (18%)
• Similarity: 181/546 - (33%)
• Gaps: 171/546 - (31%)

  Fly     6 WKP-------EPSSEDNDDDHKESKKKLK--------------------------KEGAGG---- 33
            |.|       :.|||..:::.||.:..::                          .||..|
Mouse    25 WGPHHHHRQQQDSSESEEEEEKEKESGMELDEGDSPRDLVAFANSCTLHGASHVFVEGGPGPRQA 89

  Fly    34 -WASTRRYARIPLKIMAALATVYVSILSSERYFYYWVQTSIERTD-MHVSEIDFPAVTIIPINLS 96
             ||         :..:.||......:  .:|..||.....:...| :..:|:.|||||.  .|.:
Mouse    90 LWA---------VAFVIALGAFLCQV--GDRVAYYLSYPHVTLLDEVATTELVFPAVTF--CNTN 141

  Fly    97 ILKAEKLSKAYNLVQSVVWQTPMSARLTDENFTEFSEL-----ENWNAQSWGIYQALQMNC---Q 153
            .::..:||     ...:::..||..  .||:......|     |.::.:.:.:::....:|   :
Mouse   142 AVRLSQLS-----YPDLLYLAPMLG--LDESDDPGVPLAPPGPEAFSGEPFNLHRFYNRSCHRLE 199

  Fly   154 HFFTECQWRRKAMNC---C--DLFRPTKTFNGFAFEFNSLVSSGRDETWPWSVASCGSYSGLNVK 213
            .....|.:      |   |  ..|....|..|..:.||    ||:|..........|:.:||.:.
Mouse   200 DMLLYCSY------CGGPCGPHNFSVVFTRYGKCYTFN----SGQDGRPRLKTMKGGTGNGLEIM 254

  Fly   214 IKRQQGLYTLNTMGVIVHEPTQLLGMSIDYSSEDRIVVPVEPLHFTAELDVRARP--------VQ 270
            :..||..| |...|. ..|.:...|:.:...|:|      || .|..:|.....|        .:
Mouse   255 LDIQQDEY-LPVWGE-TDETSFEAGIKVQIHSQD------EP-PFIDQLGFGVAPGFQTFVSCQE 310

  Fly   271 MRRCYFENEIPTGK--------------SRSECIYKCHVNYIISKCNCSL-ELPVKA---TQDED 317
            .|..|..:  |.|.              |.:.|...|...|::..|||.: .:|..|   |.::
Mouse   311 QRLIYLPS--PWGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQ- 372

  Fly   318 NIAAAKESNGRRICGVKDLACFNQHRLSLFSMSNIIEESRDNVFSTVDCGCFPQCGHTQYHTSTY 382
                .||             |.:.      ::..::|:.::.      |.|...|..|:|.....
Mouse   373 ----YKE-------------CADP------ALDFLVEKDQEY------CVCEMPCNLTRYGKELS 408

  Fly   383 TEKMSAHTN---LAA------------AIEIDVYFQEETLFSYRSMLRFTLIDLMVSYGGIAGLI 432
            ..|:.:..:   ||.            .:.:|::|:.....:......:.:..|:...||..||.
Mouse   409 MVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLF 473

  Fly   433 MGISVLGCINELLD------RFACCR 452
            :|.|:| .:.||.|      :...||
Mouse   474 IGASIL-TVLELFDYAYEVIKHRLCR 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk30	NP_651706.1	ASC	47..446	CDD:459966	88/453 (19%)
Asic1	NP_001276720.1	ENaC	63..541	CDD:273304	96/508 (19%)