DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk30 and Asic2

DIOPT Version :9

Sequence 1:	NP_001263076.1	Gene:	ppk30 / 43487	FlyBaseID:	FBgn0039677	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	XP_006532059.1	Gene:	Asic2 / 11418	MGIID:	1100867	Length:	596	Species:	Mus musculus

Alignment Length:	555	Identity:	110/555 - (19%)
Similarity:	180/555 - (32%)	Gaps:	158/555 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SATAWKPEPSSEDNDDDH----------KESKKKLKKEG-----AGGWASTRRYARIPLKIMAAL 51
            :|.|...:|..:.:.|..          :.|..:.|..|     ||..|:...:.|..|.::|..
Mouse    30 AAVAAARQPGGDRSGDRELQGPGVARRGRPSLSRTKLHGLRHMCAGRTAAGGSFQRRALWVLAFC 94

  Fly    52 ATVYVSILSSERYFYYWVQTSIERTDMH---VSEIDFPAVTIIPINLSILKAEKLSKAYNLVQSV 113
            .::.:.:..|.....||:... ..|.:|   ..::.|||||:  .|.:.|:..:|||. :|..:.
Mouse    95 TSLGLLLSWSSNRLLYWLSFP-SHTRVHREWSRQLPFPAVTV--CNNNPLRFPRLSKG-DLYYAG 155

  Fly   114 VW---------QTPMSARLT--DE----------NFTEFSELENWNAQSWGIYQALQMNCQHFFT 157
            .|         ..|:.:.|.  ||          :|..|....::...|......|....:....
Mouse   156 HWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLL 220

  Fly   158 ECQWRRK--------AMNC---------------CDLFR---------PTKTFNGFAFEFNSLVS 190
            .|::|.:        :::|               .:..|         |..|..|..:.||
Mouse   221 SCKYRGELCGPHNFSSVSCPPREPALSDPALPRSPEALRWAPGTGHQAPVFTKYGKCYMFN---- 281

  Fly   191 SGRDETWPWSVASCGSYSGLNVKIKRQQGLYTLNTMGVIVHEPTQLLGMSIDYSSEDRIVVPVEP 255
            ||.|.....:....|:.:||.:.:..||..| |...|. ..|.|...|:.:...|:.      ||
Mouse   282 SGEDGKPLLTTVKGGTGNGLEIMLDIQQDEY-LPIWGE-TEETTFEAGVKVQIHSQS------EP 338

  Fly   256 LHFTAELDVRARP--------VQMRRCYFENEIPTGKSRSE--------------CIYKCHVNYI 298
             .|..||.....|        .:.|..|...  |.|:.||.              |...|...||
Mouse   339 -PFIQELGFGVAPGFQTFVATQEQRLTYLPP--PWGECRSSEMGLDFFPVYSITACRIDCETRYI 400

  Fly   299 ISKCNCSL-ELPVKATQDEDNIAAAKESNGRRICGVKDLACFNQHRLSLFSMSNIIEESRDNVFS 362
            :..|||.: .:|                      |........||:........::.|...|.
Mouse   401 VENCNCRMVHMP----------------------GDAPFCTPEQHKECAEPALGLLAEKDSNY-- 441

  Fly   363 TVDCGCFPQCGHTQYHTSTYTEKMSAHTNLAAAIE----------------IDVYFQEETLFSYR 411
               |.|...|..|:|:......|:.:.|: |..:|                :|::|:.....:..
Mouse   442 ---CLCRTPCNLTRYNKELSMVKIPSKTS-AKYLEKKFNKSEKYISENILVLDIFFEALNYETIE 502

  Fly   412 SMLRFTLIDLMVSYGGIAGLIMGISVLGCINELLD 446
            ....:.:..|:...||..||.:|.|:| .|.||.|
Mouse   503 QKKAYEVAALLGDIGGQMGLFIGASIL-TILELFD 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk30	NP_001263076.1	ASC	47..446	CDD:279230	97/493 (20%)
Asic2	XP_006532059.1	ASC	64..590	CDD:383197	105/521 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920