Protein Alignment ppk20 and asic1a

DIOPT Version :10

• Sequence 1: NP_651705.2
• Gene: ppk20 / 43486
• FlyBaseID: FBgn0039676
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_999955.1
• Gene: asic1a / 791696
• ZFINID: ZDB-GENE-040513-2
• Length: 501
• Species: Danio rerio
• Alignment Length: 526
• Identity: 118/526 - (22%)
• Similarity: 190/526 - (36%)
• Gaps: 129/526 - (24%)

  Fly    34 YCEKSTIHCVRYLYDSHLHNLER-------FVVYPLFISTFNFKLYIIIVFRIIWSMLLIISIGL 91
            :...||:|.:     ||:.:.|:       :||:  |:|:..|.:|:.| .||
Zfish    26 FAHTSTLHGI-----SHIFSYEKITAKCCLWVVF--FLSSLTFLMYVCI-DRI------------ 70

  Fly    92 SFFFYLLLSERFVSQKLQTVVHDPQFPVFLVPFPAVGICTDN-----RINWNKLEAAKEQFLPTN 151
              .|||.........::.|       ||.:  ||||.||..|     ||..|.|..|.|.....|
Zfish    71 --QFYLEYPHVTKLDEITT-------PVMV--FPAVTICNLNSIRFSRITRNDLYHAGELLALLN 124

  Fly   152 ASVELVESFTVLVSRMETLRFGSYLSSLAELEDDNLEAVGFVNLTELAIFMTLQCSDIMVPKSCL 216
            :..|:.|:..|..|.||.|:..:...|......:..|   |.|.|...|      .|:::  ||.
Zfish   125 SRHEVREAHLVEESVMEVLKSKTDFRSFKPRHFNMWE---FYNRTGHDI------KDMLL--SCQ 178

  Fly   217 WRSSSFNCC--EYFVLEKTEFGFCLVFNS-EVSPRSKAIKQKEGNNFYPRHNAKAGQSTGLNFDL 278
            :|.|.   |  |.|.:..|.:|.|..||| |..|              ||.:.|.|...||...|
Zfish   179 FRGSP---CRPEDFSVVFTRYGKCYTFNSGETGP--------------PRVSVKGGMGNGLEIML 226

  Fly   279 ILNESFRRP--------DSQANNNVYVSICQAPDQLNNVVYSITQNTETYVTVRPGLTWTDNTTR 335
            .:.:....|        ..:|...|.:.....|..::.:.:.:....:|:|:.:
Zfish   227 DIQQDEYLPVWGESDESSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQ----------- 280

  Fly   336 SIPPERRNCLFADEQGELDANDSAKNFGKPFQLSNCLNRCHESYLIQLCNCSLPIFFLYNHR--- 397
                |:|........|...:...:.::.:.:.:|.|...|...||::.|||.:.      |.
Zfish   281 ----EQRLVYLPAPWGSCKSTPPSSDYFRAYSISACRTDCETRYLVENCNCRMV------HMPGD 335

  Fly   398 VPDCNAVSLRCLARHNDIFSYDKRRDEDALFSATKLGMTCSCLVDCYLLDY--------YTSTTT 454
            .|.|..|..:..|  :....:....|.|          .|||...|.:..|        ..|..:
Zfish   336 APYCTPVLYKECA--HPALDFLVETDSD----------YCSCETPCNITRYSKELSFVKIPSKAS 388

  Fly   455 LPLSAHKLPKDPH---QKLFRVDVHYQVETTPLYRTSLEFTIIDLIANLGGIFGLCLGASMVSAF 516
            :...|.|..|...   :.:..:||.::............:.:..|:.::||..||.:|||:::..
Zfish   389 VKYLAKKYSKSEKYITENVMVLDVFFEALNYETIEQRKAYEVAGLLGDIGGQMGLFIGASILTIL 453

  Fly   517 ELIYYL 522
            ||..||
Zfish   454 ELFDYL 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk20	NP_651705.2	ASC	34..521	CDD:459966	116/523 (22%)
asic1a	NP_999955.1	ENaC	23..469	CDD:273304	118/526 (22%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	446..448		1/1 (100%)