Protein Alignment ppk20 and SCNN1B

DIOPT Version :10

• Sequence 1: NP_651705.2
• Gene: ppk20 / 43486
• FlyBaseID: FBgn0039676
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 119/615 - (19%)
• Similarity: 204/615 - (33%)
• Gaps: 209/615 - (33%)

  Fly    38 STIHCVRYLYDSHLHNLERFVVYPL------FISTFN------------------FKLYIIIVFR 78
            :|:|..:||... ||.|::...|..      :....|                  |.|.::....
Human    18 ATMHVKKYLLKG-LHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFLLTLLFAAL 81

  Fly    79 IIWSMLLIISIGLSFFFYLLLSERFVSQKLQTVVHDPQFPVFLVPFPAVGICTDNRINWNK---- 139
            :.|...:.|...||:...:.||..|.:                :.||||.||..:...::|
Human    82 VCWQWGIFIRTYLSWEVSVSLSVGFKT----------------MDFPAVTICNASPFKYSKIKHL 130

  Fly   140 -------LEAAKEQFLP-----TNASVEL---VESFTVLV------------------------- 164
                   :||..|:.|.     .||:..|   :.:.|.||
Human   131 LKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTS 195

  Fly   165 -SRMETL------RFGSYLSSLAELEDDNLEAVGFVNLTELAIFMT----LQCSDI--MVPK--- 213
             |..|.:      :....|.||      |.....|.|.|.....:|    ||.::|  .||:
Human   196 SSASEKICNAHGCKMAMRLCSL------NRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQEL 254

  Fly   214 ------------SCLWRSSSFNCCEYFVLEKTEFGFCLVFNSEVSPRSKAIKQKEGNNFYPRHNA 266
                        :||:.:...|...:..:....:|.|.:||..::  .||:.           :|
Human   255 VEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT--EKALP-----------SA 306

  Fly   267 KAGQSTGLNFDLILNESFRRPDSQANNNVYVSICQA---PDQLNNVVYSITQNTETYVTV----- 323
            ..|...||...|.:.:....|...:...|.:.:.:.   |...:..:|::: .|||.:.|
Human   307 NPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMS-GTETSIGVLVDKL 370

  Fly   324 -RPGLTWTDNTTRSIPPERRNCLFADEQGELDANDSAKNFGKPFQLSNCLNRCHESYLIQLCNCS 387
             |.|..::..|...              .|:...:...::...:.:..||..|.:.::|:.|||.
Human   371 QRMGEPYSPCTVNG--------------SEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCG 421

  Fly   388 LPIFFLY----------NHRVPDCNAVSLRCLARHNDIFSYDKRRDEDALFSATKLGMTCSCLVD 442
               .:||          |...||.    ..|   ::|:.....:|:       |.:||   |...
Human   422 ---HYLYPLPRGEKYCNNRDFPDW----AHC---YSDLQMSVAQRE-------TCIGM---CKES 466

  Fly   443 CYLLDY--YTSTTTLPLSA------HKLPKDPHQK---------LFRVDVHYQVETTPLYRT--- 487
            |....|  ..|....|..|      |.|.::..|.         :.::::::|...   |||
Human   467 CNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFN---YRTIEE 528

  Fly   488 SLEFTIIDLIANLGGIFGLCLGASMVSAFE 517
            |....|:.|::||||.||..:|.|::...|
Human   529 SAANNIVWLLSNLGGQFGFWMGGSVLCLIE 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk20	NP_651705.2	ASC	34..521	CDD:459966	119/615 (19%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	111/592 (19%)