Protein Alignment ppk20 and ASIC5

DIOPT Version :10

• Sequence 1: NP_651705.2
• Gene: ppk20 / 43486
• FlyBaseID: FBgn0039676
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 107/530 - (20%)
• Similarity: 197/530 - (37%)
• Gaps: 130/530 - (24%)

  Fly    64 ISTFNFKLYIII-----VFRIIWSMLLIISIGL-SFFFYLLLSERFVSQKLQTVVHDPQFPVFLV 122
            |||....::.|:     :.|::|.::::.|:.| ::..|:.|...|......::  :.|: |..:
Human    43 ISTSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSI--EVQY-VEKM 104

  Fly   123 PFPAVGICTDNRINWNKLEAAKEQFLPTNASVELVESFTVLVSRMETLRFGSYLSSLAELEDDNL 187
            .||||..|..||.                 ..:.|..|.|:      ......:|.:..|::...
Human   105 EFPAVTFCNLNRF-----------------QTDAVAKFGVI------FFLWHIVSKVLHLQEITA 146

  Fly   188 EAVGFVNLTELAI-FMTLQCSDIMVPKSCLWRSSSFNCCEYF-----------VLEKTEFGFCLV 240
            .:.|....|:.|. .......:.:..|.....:|:...||:|           |.  ||:|.|..
Human   147 NSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVF--TEYGNCFT 209

  Fly   241 FNSEVSPRSKAIKQKEGNNFYPRHNAKAGQSTGLNFDLILNESFRRPDSQANNNV---YVSICQA 302
            ||...:.::|            |..:.:|:...|.|: :..|:|  .|:.|...|   .:.:..:
Human   210 FNHGETLQAK------------RKVSVSGRGLSLLFN-VNQEAF--TDNPALGFVDAGIIFVIHS 259

  Fly   303 P---DQLNNVVYSITQNTETYVTVRPGLT------WTDNTTRSIPPERRNCLFADEQGELDANDS 358
            |   .|.:.:...........||:|...|      |                     ||.:.|..
Human   260 PKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPW---------------------GECNPNIK 303

  Fly   359 AKNFGKPFQLSNCLNRCHESYLIQLCNCSLPIFFLYNHRVPDCNAVS-LRCLARHNDIFSYDKRR 422
            .:||.. :..|.||..|...::.:.|.| :| |.|..:.: :|:... ..|::...|...:
Human   304 LQNFSS-YSTSGCLKECKAQHIKKQCGC-VP-FLLPGYGI-ECDLQKYFSCVSPVLDHIEF---- 360

  Fly   423 DEDALFSATKLGMTCSCLVDCYLLDY--------YTSTTTLPLSAHKL---PKDPHQKLFRVDVH 476
             :|.....|.   ..||.|.|..::|        :.|...|...:.||   .|...:.|.:::::
Human   361 -KDLCTVGTH---NSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEIN 421

  Fly   477 YQVETTPLYRTSLEFTIIDLIANLGGIFGLCLGASMVSAFELIYYLTVGLAMHLYDHQYYGVLFK 541
            |......:.:.....::.:|:|:|||..||..|||:::..|:|.|        |:.:.|:..:|.
Human   422 YSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEY--------LFTNFYWICIFF 478

  Fly   542 HLK----AKW 547
            .||    .:|
Human   479 LLKISEMTQW 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk20	NP_651705.2	ASC	34..521	CDD:459966	100/498 (20%)
ASIC5	NP_059115.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	100/498 (20%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)