Protein Alignment ppk20 and asic4b

DIOPT Version :10

• Sequence 1: NP_651705.2
• Gene: ppk20 / 43486
• FlyBaseID: FBgn0039676
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_999951.1
• Gene: asic4b / 407667
• ZFINID: ZDB-GENE-040513-6
• Length: 558
• Species: Danio rerio
• Alignment Length: 621
• Identity: 131/621 - (21%)
• Similarity: 215/621 - (34%)
• Gaps: 194/621 - (31%)

  Fly     2 AKGDNSVKPTEAAGFG-------DNERCLADLLKVHFRSYCEKSTIH-CVRYLYDSHLHNLERFV 58
            |||.:    ||..|.|       ..:..:|||     .|:...|::| ..|.|..|     ||
Zfish    17 AKGAS----TEGGGTGMLDEGLRRQKEGMADL-----ASFASSSSLHGLARALGTS-----ER-- 65

  Fly    59 VYPLFISTFNFKLYIIIVFRIIWSMLLIISIGLSFFFYLLLSERFVSQKLQTVVHDPQFPVFL-- 121
                    ..|:       :.:|.:.|::|:||  |.|.      .:....|.:..|......
Zfish    66 --------LGFR-------QTLWGLALLVSLGL--FLYQ------ATWSAATYLERPHLAALREE 107

  Fly   122 ----VPFPAVGICTDNRINWNKLEAAKEQFLPTNASVELVESFTVLVSRMETLRFGSYLSSLAEL 182
                :.|||:.:|..||..::.|         |:|.:..:.:.|.|..:.   |.|...|.| :.
Zfish   108 TRRELTFPAITLCNVNRFRFSAL---------TDADIYHLANLTGLPPKS---RKGHRPSEL-QY 159

  Fly   183 EDDNLEAVGFVNLTELAIFMTL--QCSDIMVPKSCLWRSSSFNC-CEYFVLEKTEFGFCLVFNSE 244
            ...|:          |.||...  |..|::  |||  ..|..|| .|.|.:..|.:|.|..||
Zfish   160 PPPNM----------LDIFQRTGHQLEDML--KSC--NFSGQNCSSEDFSVVYTRYGKCYTFN-- 208

  Fly   245 VSPRSKAIKQKEGNNFYPRHNAKAGQSTGLNFDLILNESFRRP--------DSQANNNVYVSICQ 301
                        ||...|:...:.|...||...|.:.:....|        ..:|...|.:....
Zfish   209 ------------GNKTSPKRVRQGGTGNGLEMMLDIQQDEYLPIWRETNETTLEAGIRVQIHSQN 261

  Fly   302 APDQLNNVVYSITQNTETYVTVR-PGLTWTDNTTRSIPPERRNCLFADEQGELDANDSAKNFGKP 365
            .|..::.:.:.::...:|:|:.: ..||:       :|....||. |..:..:...|:
Zfish   262 EPPYIHQLGFGVSPGFQTFVSCQEQRLTY-------LPQPWGNCR-ASSEPVIPGYDT------- 311

  Fly   366 FQLSNCLNRCHESYLIQLCNCSLPIFFLYNHRVPD---CNAVSLRCLARHNDIFSYDKRRDEDAL 427
            :.:|.|...|..:.:.:.|||.:.      |...|   |....::|:         ||     ||
Zfish   312 YSVSACRLHCESTQVQRECNCRMV------HMPGDADICAPSKIKCV---------DK-----AL 356

  Fly   428 FSATK-LGMTCSCLVDCYLLDYYTSTTTLPLSAHKLP--------KDPHQK--------LFRVDV 475
            .|..| .|.:|.|...|.|..|...     ||..|:|        ...:||        ...:|:
Zfish   357 ASLQKSTGDSCPCETPCNLTRYGKE-----LSMVKIPSRGSARYLSRKYQKSEEYIRDNFLILDI 416

  Fly   476 HYQVETTPLYRTSLEFTIIDLIANLGGIFGLCLGASMVSAFELIYYLTVGLAMHLYDHQYYGVLF 540
            .::............:.|..|:.::||..||.:|||:::..|::.|:             |.|
Zfish   417 FFEALNYETIEQKKAYDIAGLLGDIGGQMGLFIGASILTILEILDYI-------------YEV-- 466

  Fly   541 KHLKAKWVNLKGYLRNEVGHLAENPAAHKDTNDRKL 576
                         .:|::..|.:...:.|.||.|.|
Zfish   467 -------------AKNKIKQLLKPKKSQKQTNQRNL 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk20	NP_651705.2	ASC	34..521	CDD:459966	110/525 (21%)
asic4b	NP_999951.1	ENaC	54..497	CDD:273304	119/575 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	450..452		1/1 (100%)