Protein Alignment ppk20 and Asic4

DIOPT Version :10

• Sequence 1: NP_651705.2
• Gene: ppk20 / 43486
• FlyBaseID: FBgn0039676
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: XP_036020902.1
• Gene: Asic4 / 241118
• MGIID: 2652846
• Length: 586
• Species: Mus musculus
• Alignment Length: 629
• Identity: 126/629 - (20%)
• Similarity: 224/629 - (35%)
• Gaps: 173/629 - (27%)

  Fly     5 DNSVKPTEAAGFGDNERCLA---------DLLKVHFRSYCEKSTIHCVRYLYDSHLHNLERFVVY 60
            :...||.|... ||.:..|.         ||     .::...||:|.:........|.|.
Mouse    13 EEDAKPKEKEA-GDEQSLLGAAQGPAAPRDL-----ATFASTSTLHGLGRACGPGPHGLR----- 66

  Fly    61 PLFISTFNFKLYIIIVFRIIWSMLLIISIGLSFFFYLLLSERFVSQKLQTVVHDPQFPVFLVPFP 125
                             |.:|::.|:.|:....:....|:..::::. ..|..||..|..:..||
Mouse    67 -----------------RTLWALALLTSLAAFLYQAASLARGYLTRP-HLVAMDPAAPAPVAGFP 113

  Fly   126 AVGICTDNRINWNKLEAAKEQFLPTNASVELVESFTVLVSRMETLRFGSYLSSLAELEDDNLEAV 190
            ||.:|..||...:.|         ::|.:..:.:.|.|..:.   |.|...:.|...|.|   .|
Mouse   114 AVTLCNINRFRHSAL---------SDADIFHLANLTGLPPKD---RDGHRAAGLRYPEPD---MV 163

  Fly   191 GFVNLTELAIFMTLQCSDIMVPKSCLWRSSSFNC-CEYFVLEKTEFGFCLVFNSEVSPRSKAIKQ 254
            ..:|.|      ..|.:|::  |||  ..|..:| ...|.:..|.:|.|..||::  |:| ::..
Mouse   164 DILNRT------GHQLADML--KSC--NFSGHHCSASNFSVVYTRYGKCYTFNAD--PQS-SLPS 215

  Fly   255 KEGNNFYPRHNAKAGQSTGLNFDLILNESFRRP--------DSQANNNVYVSICQAPDQLNNVVY 311
            :.|           |..:||...|.:.:....|        ..:|...|.:...:.|..::.:.:
Mouse   216 RAG-----------GMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGF 269

  Fly   312 SITQNTETYVTVR-PGLTWTDNTTRSIPPERRNCLFADE--QGELDANDSAKNFGKPFQLSNCLN 373
            .::...:|:|:.: ..||:       :|....||....|  :.||....:       :.:|.|..
Mouse   270 GVSPGFQTFVSCQEQRLTY-------LPQPWGNCRAESELREPELQGYSA-------YSVSACRL 320

  Fly   374 RCHESYLIQLCNCSL---------PIF---------------------FLYNH-RVPDCNAVSLR 407
            ||.:..::|.|:|.:         |:|                     .:|.| ||       |.
Mouse   321 RCEKEAVLQRCHCRMVHMPGGHLQPVFGATLLSSRTSRRQRCMRTTCTRIYTHERV-------LM 378

  Fly   408 CLARH----NDIFSYDKRRDEDALFSATKLG----MTCSCLVDCYLLDYYTSTTTLPL----SAH 460
            |::.:    |:.........|.|..:...||    ..|.|...|.|..|....:.:.:    ||.
Mouse   379 CMSGYLHMGNETICPPNIYIECADHTLDSLGGGSEGPCFCPTPCNLTRYGKEISMVKIPNRGSAR 443

  Fly   461 KLPKDPH-------QKLFRVDVHYQVETTPLYRTSLEFTIIDLIANLGGIFGLCLGASMVSAFEL 518
            .|.:..:       :....:||.::..|:........:.:..|:.:|||..||.:|||:::..|:
Mouse   444 YLARKYNRNETYIRENFLVLDVFFEALTSEAMEQQAAYGLSALLGDLGGQMGLFIGASILTLLEI 508

  Fly   519 IYYLTVGLAMHLYDHQYYGVLFKHLKAKWVNLKGYLRNEVGHLA 562
            :.|:             |.|.:..||..|...|..||...|.::
Mouse   509 LDYI-------------YEVSWDRLKRVWRRPKTPLRTSTGGIS 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk20	NP_651705.2	ASC	34..521	CDD:459966	108/548 (20%)
Asic4	XP_036020902.1	ENaC	40..535	CDD:273304	119/595 (20%)