Protein Alignment ppk20 and Asic1

DIOPT Version :10

• Sequence 1: NP_651705.2
• Gene: ppk20 / 43486
• FlyBaseID: FBgn0039676
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_001276720.1
• Gene: Asic1 / 11419
• MGIID: 1194915
• Length: 559
• Species: Mus musculus
• Alignment Length: 555
• Identity: 106/555 - (19%)
• Similarity: 177/555 - (31%)
• Gaps: 172/555 - (30%)

  Fly    80 IWSMLLIISIG-------------LSFFFYLLLSERFVSQKLQTVVHDPQFPVFLVPFPAVGICT 131
            :|::..:|::|             ||:....||.|...::               :.||||..|.
Mouse    90 LWAVAFVIALGAFLCQVGDRVAYYLSYPHVTLLDEVATTE---------------LVFPAVTFCN 139

  Fly   132 DNRINWNKLEAAKEQFL--------PTNASVELV----ESFTVLVSRMETLRFGSYLSSLAELED 184
            .|.:..::|......:|        ..:..|.|.    |:|:.....:.  ||  |..|...|||
Mouse   140 TNAVRLSQLSYPDLLYLAPMLGLDESDDPGVPLAPPGPEAFSGEPFNLH--RF--YNRSCHRLED 200

  Fly   185 DNLEAVGFVNLTELAIFMTLQCSDIMVPKSCLWRSSSFNCCEY-FVLEKTEFGFCLVFNS--EVS 246
                             |.|.||....|           |..: |.:..|.:|.|..|||  :..
Mouse   201 -----------------MLLYCSYCGGP-----------CGPHNFSVVFTRYGKCYTFNSGQDGR 237

  Fly   247 PRSKAIKQKEGNNFYPRHNAKAGQSTGLNFDLILNESFRRP--------DSQANNNVYVSICQAP 303
            ||.|.:|...||              ||...|.:.:....|        ..:|...|.:.....|
Mouse   238 PRLKTMKGGTGN--------------GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEP 288

  Fly   304 DQLNNVVYSITQNTETYVTVRPGLTWTDNTTRSIPPERRNCLFADEQGELDANDSAKNFGKPFQL 368
            ..::.:.:.:....:|:|:.:               |:|........|..:|.....:|...:.:
Mouse   289 PFIDQLGFGVAPGFQTFVSCQ---------------EQRLIYLPSPWGTCNAVTMDSDFFDSYSI 338

  Fly   369 SNCLNRCHESYLIQLCNCSLPIFFLYNHR---VPDCNAVSLRCLARHNDIFSYDKRRDEDALFSA 430
            :.|...|...||::.|||.:.      |.   .|.|...            .|.:..|....|..
Mouse   339 TACRIDCETRYLVENCNCRMV------HMPGDAPYCTPE------------QYKECADPALDFLV 385

  Fly   431 TKLGMTCSCLVDCYLLDYYTSTTTLPLSAHKLPKDPHQK----------------LFRVDVHYQV 479
            .|....|.|.:.|.|..|...     ||..|:|.....|                :..:|:.::|
Mouse   386 EKDQEYCVCEMPCNLTRYGKE-----LSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEV 445

  Fly   480 ETTPLYRTSLEFTIIDLIANLGGIFGLCLGASMVSAFELIYYLTVGLAMHLYDHQYYGVLFKHLK 544
            ...........:.|..|:.::||..||.:|||:::..|            |:|:.|  .:.||..
Mouse   446 LNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLE------------LFDYAY--EVIKHRL 496

  Fly   545 AKWVNLKGYLRNEVGHLAENPAAHKDTNDRKLRHP 579
            .:    :|..:.|....:.:.......:|.|..:|
Mouse   497 CR----RGKCQKEAKRNSADKGVALSLDDVKRHNP 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk20	NP_651705.2	ASC	34..521	CDD:459966	96/495 (19%)
Asic1	NP_001276720.1	ENaC	63..541	CDD:273304	106/555 (19%)