Protein Alignment ppk20 and Asic2

DIOPT Version :10

• Sequence 1: NP_651705.2
• Gene: ppk20 / 43486
• FlyBaseID: FBgn0039676
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: XP_006532059.1
• Gene: Asic2 / 11418
• MGIID: 1100867
• Length: 596
• Species: Mus musculus
• Alignment Length: 601
• Identity: 119/601 - (19%)
• Similarity: 201/601 - (33%)
• Gaps: 202/601 - (33%)

  Fly    78 RIIWSMLLIISIGLSFFFYLLLSERFVSQKL--------QTVVH---DPQFPVFLVPFPAVGICT 131
            |.:|.:....|:|      ||||  :.|.:|        .|.||   ..|     :|||||.:|.
Mouse    86 RALWVLAFCTSLG------LLLS--WSSNRLLYWLSFPSHTRVHREWSRQ-----LPFPAVTVCN 137

  Fly   132 DNRINWNKLEAAKEQF--------LPTNASVELVESFTVLVSRMETLR----------------- 171
            :|.:.:.:|......:        ||...:..||.         |.||
Mouse   138 NNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVS---------ELLRGDEPRRQWFRKLADFRL 193

  Fly   172 ----------FGSYLSSLA-ELEDDNL------EAVGFVNLTELAIFMTLQC-------SDIMVP 212
                      ..:::..|. :|||..|      |..|..|      |.::.|       ||..:|
Mouse   194 FLPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGPHN------FSSVSCPPREPALSDPALP 252

  Fly   213 KS---CLWRSSSFNCCEYFVLEKTEFGFCLVFNSEVSPRSKAIKQKEGNNFYP-RHNAKAGQSTG 273
            :|   ..|...:.:....|    |::|.|.:|||             |.:..| ....|.|...|
Mouse   253 RSPEALRWAPGTGHQAPVF----TKYGKCYMFNS-------------GEDGKPLLTTVKGGTGNG 300

  Fly   274 LNFDLILNESFRRP--------DSQANNNVYVSICQAPDQLNNVVYSITQNTETYV-TVRPGLTW 329
            |...|.:.:....|        ..:|...|.:.....|..:..:.:.:....:|:| |....||:
Mouse   301 LEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTY 365

  Fly   330 TDNTTRSIPPERRNCLFADEQGELDANDSAKNFGKPFQLSNCLNRCHESYLIQLCNCSL------ 388
                   :||         ..||..:::...:|...:.::.|...|...|:::.|||.:
Mouse   366 -------LPP---------PWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGD 414

  Fly   389 -PIFFLYNHRVPDCNAVSLRCLARHNDIFSYDKRRDEDALFSATKLGMTCSCLVDCYLLDY---- 448
             |......|:  :|...:|..||            ::|:.:        |.|...|.|..|
Mouse   415 APFCTPEQHK--ECAEPALGLLA------------EKDSNY--------CLCRTPCNLTRYNKEL 457

  Fly   449 -------YTSTTTLPLSAHKLPKDPHQKLFRVDVHYQVETTPLYRTSLEFTIIDLIANLGGIFGL 506
                   .||...|....:|..|...:.:..:|:.::............:.:..|:.::||..||
Mouse   458 SMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGL 522

  Fly   507 CLGASMVSAFELIYYLTVGLAMHLYDHQYYGVLFKHLKAKWVNLKGYLRNEVGHLAENPAA---- 567
            .:|||:::..||..|                 :::.:|.|.::|.|....|..| .||.:.
Mouse   523 FIGASILTILELFDY-----------------IYELIKEKLLDLLGKEEEEGSH-DENMSTCDTM 569

  Fly   568 --HKDTNDRKLRHPFN 581
              |.:|    :.|..|
Mouse   570 PNHSET----ISHTVN 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk20	NP_651705.2	ASC	34..521	CDD:459966	106/533 (20%)
Asic2	XP_006532059.1	ENaC	64..590	CDD:273304	119/601 (20%)