Protein Alignment ppk21 and asic1a

DIOPT Version :10

• Sequence 1: NP_651704.2
• Gene: ppk21 / 43485
• FlyBaseID: FBgn0039675
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_999955.1
• Gene: asic1a / 791696
• ZFINID: ZDB-GENE-040513-2
• Length: 501
• Species: Danio rerio
• Alignment Length: 537
• Identity: 103/537 - (19%)
• Similarity: 196/537 - (36%)
• Gaps: 168/537 - (31%)

  Fly    46 PYLKDYAAESSVHGIRYLADPKMRNYLNIRV---IWLLILLTTSIGAIVVYVDLNELYQTVRIQT 107
            |.|:.:|..|::|||.::.     :|..|..   :|::..|::....:.|.:|..:.|......|
Zfish    21 PPLQVFAHTSTLHGISHIF-----SYEKITAKCCLWVVFFLSSLTFLMYVCIDRIQFYLEYPHVT 80

  Fly   108 TIKNTMLPIFRIPFPSIGLCPRNRLNWKILETEAVDHFLGANVSAAQKDLFVKFFTAAGDPHLSR 172
            .:.....|:  :.||::.:|..|.:.:..:               .:.||:          |...
Zfish    81 KLDEITTPV--MVFPAVTICNLNSIRFSRI---------------TRNDLY----------HAGE 118

  Fly   173 LNEMSNFFGNKTLTDELHMLD-------------------HLDLREVYKFIQFRCQDLFHTCRWR 218
            |..:.|   ::....|.|:::                   |.::.|.|.......:|:..:|::|
Zfish   119 LLALLN---SRHEVREAHLVEESVMEVLKSKTDFRSFKPRHFNMWEFYNRTGHDIKDMLLSCQFR 180

  Fly   219 GNPVNCCEVIEYQ--FTEAGLCFVFNT-EISPASRQKAREDKYYPLRTPHYGEGSGLDLFLRLNR 280
            |:|   |...::.  ||..|.|:.||: |..|            |..:...|.|:||::.|.:.:
Zfish   181 GSP---CRPEDFSVVFTRYGKCYTFNSGETGP------------PRVSVKGGMGNGLEIMLDIQQ 230

  Fly   281 SFIRP---------GKRGINVMIKQPQQWSDVVRHVPHEAHTRISITPRFTVTDERTRTVTPEIR 336
            ....|         .:.||.|.|....:       .|........:.|.|..      .|:.:.:
Zfish   231 DEYLPVWGESDESSFEAGIKVQIHSQDE-------PPFIDQLGFGVAPGFQT------FVSCQEQ 282

  Fly   337 RCIF-----GDEVDNPHYKNFPDFEYW----VGNCRSRCHQEHVLNLCKC--------------- 377
            |.::     |.....|     |..:|:    :..||:.|...:::..|.|
Zfish   283 RLVYLPAPWGSCKSTP-----PSSDYFRAYSISACRTDCETRYLVENCNCRMVHMPGDAPYCTPV 342

  Fly   378 ------SPSIFFPISDKDNFTACKASDFKCLYDNRFTFSIERHPEEDDFVKNPFKESM--ICDCF 434
                  .|::.|.:....::.:|:.   .|        :|.|:.:|..|||.|.|.|:  :...:
Zfish   343 LYKECAHPALDFLVETDSDYCSCET---PC--------NITRYSKELSFVKIPSKASVKYLAKKY 396

  Fly   435 TSCSQLVFDRVFTTTTLDNNETDTEAGTMRLDIFYQSGWFIQYQT---NMRFTFVELLASFGGII 496
            :...:.:.:.|                 |.||:|:::   :.|:|   ...:....||...||.:
Zfish   397 SKSEKYITENV-----------------MVLDVFFEA---LNYETIEQRKAYEVAGLLGDIGGQM 441

  Fly   497 GLFLGASLLSAFELAYY 513
            |||:|||:|:..||..|
Zfish   442 GLFIGASILTILELFDY 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:459966	100/530 (19%)
asic1a	NP_999955.1	ENaC	23..469	CDD:273304	102/535 (19%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	446..448		1/1 (100%)