DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk21 and Asic4

DIOPT Version :9

Sequence 1:	NP_651704.2	Gene:	ppk21 / 43485	FlyBaseID:	FBgn0039675	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_071570.2	Gene:	Asic4 / 63882	RGDID:	621068	Length:	539	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	115/522 - (22%)
Similarity:	188/522 - (36%)	Gaps:	109/522 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LKDYAAESSVHGIRYLADPKMRNYLNIRVIWLLILLTTSIGAIVVYVDLNELYQTVRIQTTIKNT 112
            |..:|:.|::||:.....|......  |.:|:|.|||:....:.....|...|.| |......:.
  Rat    42 LATFASTSTLHGLGRACGPGPHGLR--RTLWVLALLTSLAAFLYQAASLARGYLT-RPHLVAMDP 103

  Fly   113 MLPIFRIPFPSIGLCPRNRLNWKILETEAVDHFLGANVSA-AQKDLFVKFFTAAGDPHLS---RL 173
            ..|.....||::.||..||.....|....:.|.  ||::. ..||         .|.|.:   |.
  Rat   104 AAPAPVAGFPAVTLCNINRFRHSALSDADIFHL--ANLTGLPPKD---------RDGHRAAGLRY 157

  Fly   174 NEMSNFFGNKTLTDELHMLDHLDLREVYKFIQFRCQDLFHTCRWRGNPVNCCEVIEYQ--FTEAG 236
            .|       ..:.|.|:...|            :..|:..:|.:.|:.   |....:.  :|..|
  Rat   158 PE-------PDMVDILNRTGH------------QLADMLKSCNFSGHH---CSASNFSVVYTRYG 200

  Fly   237 LCFVFNTEISPASRQKAREDKYYPLRTPHYGEGSGLDLFLRLNRSFIRPGKR---------GINV 292
            .|:.||.:  |.|...:|..          |.||||::.|.:.:....|..|         ||.|
  Rat   201 KCYTFNAD--PQSSLPSRAG----------GMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRV 253

  Fly   293 MIKQPQQWSDVVRHVPHEAHTRISITP---RFTVTDERTRTVTPE-IRRCIFGDEVDNPHYKNFP 353
            .|...::       .|:.......::|   .|....|:..|..|: ...|....::..|..:.:.
  Rat   254 QIHSQEE-------PPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESKLREPELQGYS 311

  Fly   354 DFEYWVGNCRSRCHQEHVLNLCK------------CSPSIFFPISDKDNFTACKASDFKCLYDNR 406
              .|.|..||.||.:|.||..|.            |.|:|:...:|....:....|:..|....
  Rat   312 --AYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGSEGPCFCPT- 373

  Fly   407 FTFSIERHPEEDDFVKNPFKESMICDCFTSCSQLVFDRVFTTTTLDNNETDTEAGTMRLDIFYQS 471
             ..::.|:.:|...||.|.:.|               ..:.....:.|||......:.||:|:::
  Rat   374 -PCNLTRYGKEISMVKIPNRGS---------------ARYLARKYNRNETYIRENFLVLDVFFEA 422

  Fly   472 GWFIQYQTNMRFTFVELLASFGGIIGLFLGASLLSAFE-LAYYFSIGLYLYIHGKRKLRKPEPGV 535
            ......:....:....||...||.:|||:|||:|:..| |.|.:.:.   :...||..|:|:..:
  Rat   423 LTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVS---WDRLKRVWRRPKTPL 484

  Fly   536 LT 537
            .|
  Rat   485 RT 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:279230	108/493 (22%)
Asic4	NP_071570.2	ASC	40..488	CDD:295594	115/522 (22%)
Asic4	NP_071570.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920