Protein Alignment ppk21 and SCNN1G

DIOPT Version :9

• Sequence 1: NP_651704.2
• Gene: ppk21 / 43485
• FlyBaseID: FBgn0039675
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001030.2
• Gene: SCNN1G / 6340
• HGNCID: 10602
• Length: 649
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 114/613 - (18%)
• Similarity: 207/613 - (33%)
• Gaps: 195/613 - (31%)

  Fly    46 PYLKD----YAAESSVHGIRYLADPKMRNYLNIRVIWLLILLTTSIGAIVVYVDLNELYQTVRIQ 106
            |.:|:    |...::.||.|.:...:.|..   |::|:...||..  |::::.....::....:.
Human    23 PTIKELMRWYCLNTNTHGCRRIVVSRGRLR---RLLWIGFTLTAV--ALILWQCALLVFSFYTVS 82

  Fly   107 TTIKNTMLPIFRIPFPSIGLCPRNRLNWKIL---------ET-EAVDHFLG-------------A 148
            .:||   :...::.||::.:|..|...:..:         || ||:....|             .
Human    83 VSIK---VHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWN 144

  Fly   149 NVSAAQKDLFV-----------------KFFTA----AGDPHLSRLNEMSNFFGNKTLTDELHML 192
            :||..::..|.                 .|||.    .|...:.:.:.:.:....:.:..:|...
Human   145 SVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSN 209

  Fly   193 DHLD------------LREVYKF----------------IQFRCQDLFHTCRWRGNPVNCCEVIE 229
            |..|            ::|.||.                :.:..::|..||.:.|...:......
Human   210 DTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTL 274

  Fly   230 YQFTEAGLCFVFNTEISPASRQKAREDKYYPLRTPHYGEGSGLDLFLRLNRSFIRP---GKRGIN 291
            :.....|.|:.||.          ||::.. |.|...|...||.:.|.:|.....|   ...|..
Human   275 FHHPMHGNCYTFNN----------RENETI-LSTSMGGSEYGLQVILYINEEEYNPFLVSSTGAK 328

  Fly   292 VMIKQPQQW---SDVVRHVPHEAHTRIS--ITPRFTVTDERTRTVTPEIRRCIFGDEVDNPHYKN 351
            |:|.:..::   .||...:.....|.|.  :|..|.:::..::...         |..|.| .:|
Human   329 VIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTE---------DGSDVP-IRN 383

  Fly   352 FPDFEYWVGNCRSRCHQEHVLNLCKCSPSIFFPISDKDNFTACKASDFKCLYDNRFTFSIERHPE 416
            ..:..|.:..|...|.|..::..|.|: ....|:....|:         |.|        ::||.
Human   384 IYNAAYSLQICLHSCFQTKMVEKCGCA-QYSQPLPPAANY---------CNY--------QQHPN 430

  Fly   417 --------EDDFVKNPFKESMICD--CFTSCSQLVFDRVFTTTTLDN------------------ 453
                    ...||    :|.:.|.  |..:||   |.....||:|..
Human   431 WMYCYYQLHRAFV----QEELGCQSVCKEACS---FKEWTLTTSLAQWPSVVSEKWLLPVLTWDQ 488

  Fly   454 --------NETDTEAGTMRLDIFYQSGWFIQYQTNMRFTFVE--------LLASFGGIIGLFLGA 502
                    |:||    ..:|.|||:       ..|.| :.:|        ||::|||.:||::..
Human   489 GRQVNKKLNKTD----LAKLLIFYK-------DLNQR-SIMESPANSIEMLLSNFGGQLGLWMSC 541

  Fly   503 SLLSAFELAYYFSIGLYLYIHGKRKLRK 530
            |::...|:...|.|..:..| .:|:.:|
Human   542 SVVCVIEIIEVFFIDFFSII-ARRQWQK 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:279230	107/585 (18%)
SCNN1G	NP_001030.2	ENaC	24..630	CDD:273304	113/612 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820