DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk21 and SCNN1D

DIOPT Version :9

Sequence 1:	NP_651704.2	Gene:	ppk21 / 43485	FlyBaseID:	FBgn0039675	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001123885.2	Gene:	SCNN1D / 6339	HGNCID:	10601	Length:	802	Species:	Homo sapiens

Alignment Length:	654	Identity:	128/654 - (19%)
Similarity:	213/654 - (32%)	Gaps:	224/654 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PRARRPLYRDYGGKSGLIQTQRDARKNSRLGKLWHFMLPYLKDYAAESSVHG-IRYLADPKMRNY 71
            |.|..|..:: |.:.||::.....|:             .|..:...:::|| ||.:.....|
Human   198 PSAPPPPPKE-GHQEGLVELPASFRE-------------LLTFFCTNATIHGAIRLVCSRGNR-- 246

  Fly    72 LNIRVIWLLILLTT-----SIGAIVVYV-DLNELYQ-------TVRIQTTIKNTMLPIFRIPFPS 123
                      |.||     |:||:|... .|..|::       .:.:....:..:||:
Human   247 ----------LKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPL------- 294

  Fly   124 IGLCPRN--RLNWKILETEAVDHFLGANVSAAQKDLFVKFFTAAGDPHLSRLNEMSNFFGNKTLT 186
            :.||..|  |.:..:...|.:|.|...|:.:..            :.:||:        |...|:
Human   295 VTLCDGNPRRPSPVLRHLELLDEFARENIDSLY------------NVNLSK--------GRAALS 339

  Fly   187 DELHMLD---HLDLREVYKFIQFRCQDLFHT-----------------CRWRGNPVNCCEVIE-Y 230
            ..:...:   ||| ||:      |.|.|.|:                 |.:||.......|.: |
Human   340 ATVPRHEPPFHLD-REI------RLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWY 397

  Fly   231 QFTEAGLCFVFNTEISPASRQKAR--EDKYYPLRTPHYGEGSGLDLFLRLNRSF----------- 282
            .|.     :|....:.||:.:.:.  :|.::.|...:    .|||...|..|:|
Human   398 HFH-----YVDILALLPAAWEDSHGSQDGHFVLSCSY----DGLDCQARQFRTFHHPTYGSCYTV 453

  Fly   283 ------IRPG-KRGINVMIKQPQQ-----WSDVV---------RHVPHEAHTRISITPRFTVT-- 324
                  .||| ..|:.::::..||     .|.:.         .|.|...|...|:.|....|
Human   454 DGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATIS 518

  Fly   325 ---DERTRTVTPEIRRCIFGD---EVDNPHYKNFPDFEYWVGNCRSRCHQEHVLNLCKCSPSIF- 382
               ||..|..:| ...|..|.   ||:..|     :..|....|...|.|:.::..|.|...:.
Human   519 IREDEVHRLGSP-YGHCTAGGEGVEVELLH-----NTSYTRQACLVSCFQQLMVETCSCGYYLHP 577

  Fly   383 FPISDKDNFTACKASDFKCLYDNRFTFSIERHPEEDDFVKNPFKESMICDCFTSCSQLVFDRVFT 447
            .|...:...:|...:...|.|  |....:|.|       :.|        |.:.|.:...:..|.
Human   578 LPAGAEYCSSARHPAWGHCFY--RLYQDLETH-------RLP--------CTSRCPRPCRESAFK 625

  Fly   448 TTTLDNNETDTEAGTMRLDIFYQSGW-------------------------FIQYQTNMR----- 482
            .:|          ||.|......:||                         .:..:.|.|
Human   626 LST----------GTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEA 680

  Fly   483 --FTFVELLASFGGIIGLFLGASLLSAFELAYYF--SIGLYLYIHGKRKLR--------KPEPGV 535
              ::..:||::.|.:..|:.|||:||..||....  :..|.|.:.|:|..|        .|..|.
Human   681 PVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGA 745

  Fly   536 LTIQ 539
            .:|:
Human   746 SSIK 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:279230	112/573 (20%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..211		4/13 (31%)
		ENaC	219..784	CDD:273304	122/632 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..777		3/12 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820