Protein Alignment ppk21 and SCNN1B

DIOPT Version :10

• Sequence 1: NP_651704.2
• Gene: ppk21 / 43485
• FlyBaseID: FBgn0039675
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 108/581 - (18%)
• Similarity: 188/581 - (32%)
• Gaps: 192/581 - (33%)

  Fly    51 YAAESSVHGIRYL--ADPKMRNYLNIRVIWLLILLTTSIGAIV---------------VYVDLNE 98
            |...::.||.:.:  ..||.      :.:|  .|||....|:|               |.|.|:.
Human    48 YCDNTNTHGPKRIICEGPKK------KAMW--FLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSV 104

  Fly    99 LYQTVRIQTTIKNTMLPIFRIPFPSIGLCPRNRLNWKILE---------TEAV-DHFLGANVSAA 153
            .::|                :.||::.:|..:...:..::         .||| :..|...:|.|
Human   105 GFKT----------------MDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHA 153

  Fly   154 QK----------------------------DLFVKFFTAAGDPH--------------------- 169
            ..                            |||       ||.|
Human   154 NATRNLNFSIWNHTPLVLIDERNPHHPMVLDLF-------GDNHNGLTSSSASEKICNAHGCKMA 211

  Fly   170 --LSRLNEMSNFFGNKT-----LTDELHMLDHLDLREVYKFIQFRCQDLFH----------TCRW 217
              |..||.....|.|.|     || |.::|...::     |.|...|:|..          .|.:
Human   212 MRLCSLNRTQCTFRNFTSATQALT-EWYILQATNI-----FAQVPQQELVEMSYPGEQMILACLF 270

  Fly   218 RGNPVNCCEVIEYQFTEAGLCFVFNTEISPASRQKAREDKYYPLRTPHYGEGSGLDLFLRLNRSF 282
            ...|.|........:...|.|::||..::         :|..|...|  |...||.|.|.:.:..
Human   271 GAEPCNYRNFTSIFYPHYGNCYIFNWGMT---------EKALPSANP--GTEFGLKLILDIGQED 324

  Fly   283 IRP---GKRGINVMIKQPQQW---SDVVRHVPHEAHTRISITPRFTVTDERTRTVTPEIRRCIFG 341
            ..|   ...|:.:|:.:.:.:   .|...:......|.|.:     :.|:..|...|.....:.|
Human   325 YVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGV-----LVDKLQRMGEPYSPCTVNG 384

  Fly   342 DEVDNPHYKNFPDFEYWVGNCRSRCHQEHVLNLCKCSPSIFFPISDKDNFTACKASDF----KCL 402
            .||...::.:..:..|.:..|...|.|:|::..|.|. ...:|:...:.:  |...||    .|.
Human   385 SEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCG-HYLYPLPRGEKY--CNNRDFPDWAHCY 446

  Fly   403 YDNRFTFSIERHPEEDDFVKNPFKESMICDCFTSCSQLVF---------------DRVFTTTTLD 452
            .|  ...|:.:            :|:.|..|..||:...:               |.:|...:.:
Human   447 SD--LQMSVAQ------------RETCIGMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQE 497

  Fly   453 ----NNETDTEAGTMRLDIFYQSGWFIQYQTNMRFTFVELLASFGGIIGLFLGASLLSAFE 509
                .|.|.:..|.::|:|::|...:...:.:.....|.||::.||..|.::|.|:|...|
Human   498 RDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIE 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:459966	108/581 (19%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	108/581 (19%)