Protein Alignment ppk21 and SCNN1A

DIOPT Version :10

• Sequence 1: NP_651704.2
• Gene: ppk21 / 43485
• FlyBaseID: FBgn0039675
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 634
• Identity: 132/634 - (20%)
• Similarity: 213/634 - (33%)
• Gaps: 202/634 - (31%)

  Fly    21 KSGLIQTQRDARKNSRLGKLWHFMLPYLKDYAAESSVHG-IRYLADP--KMRNYLNIRVIWLLIL 82
            :..||:..|..|      :|:.|       :...:::|| ||.:...  :|:.     ..|.::.
Human   104 EEALIEFHRSYR------ELFEF-------FCNNTTIHGAIRLVCSQHNRMKT-----AFWAVLW 150

  Fly    83 LTTSIGAIVVYVDLNELYQTVRIQTTIKNTMLPIFRIPFPSIGLCPRNRLNWKIL--ETEAVDHF 145
            |.| .|  ::|.....|:..........|..|...::.||::.:|..|...:..:  |.|.:|..
Human   151 LCT-FG--MMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRI 212

  Fly   146 LGANVSAAQKDLFVKF----FT--AAGD----------PH-LSRLNEMSNFFGNK-------TLT 186
                   .::.||..:    ||  .||.          || |.||.......|.:       :|.
Human   213 -------TEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSVASSLR 270

  Fly   187 DELHMLDHLD--------------------------LREVYKF----IQFRCQD----------- 210
            |....:|..|                          :||.|:|    |..|..:
Human   271 DNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLG 335

  Fly   211 -LFHTCRWRGNPVNCCEVIEYQFTEA--GLCFVFNTEISPASRQKAREDKYYPLRTPHYGEGSGL 272
             ....||:  |.|:|.:.....|...  |.|:.||.:         .....:....|  |..:||
Human   336 NFIFACRF--NQVSCNQANYSHFHHPMYGNCYTFNDK---------NNSNLWMSSMP--GINNGL 387

  Fly   273 DLFLRLNRSFIRP---GKRGINVMI---KQPQQWSDVVRHVPHEAHTRISITPRFTVTDERTRTV 331
            .|.||..::...|   ...|..||:   .:|....|...::.....|.||:           |..
Human   388 SLMLRAEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISM-----------RKE 441

  Fly   332 TPEIRRCIFGDEVDN----PHYKNFPDFEYWVGNCRSRCHQEHVLNLCKCSPSIFFPISDKDNFT 392
            |.:.....:||...|    |....:|. :|....|...|.||.::..|.|: .||:|  ...|..
Human   442 TLDRLGGDYGDCTKNGSDVPVENLYPS-KYTQQVCIHSCFQESMIKECGCA-YIFYP--RPQNVE 502

  Fly   393 ACKASDFK-------CLYDNRFTFSIERHPEEDDFVKNPFKESMICDCFTSC------------- 437
            .|   |::       |.|..:..||.:.                 ..|||.|
Human   503 YC---DYRKHSSWGYCYYKLQVDFSSDH-----------------LGCFTKCRKPCSVTSYQLSA 547

  Fly   438 ---------SQLVFDRVFTTTTLDNNET--DTEAGTMRLDIFYQSGWFIQYQTNMR---FTFVEL 488
                     ||   :.||...:..||.|  :...|..:::||::.   :.|:||..   .|.|.|
Human   548 GYSRWPSVTSQ---EWVFQMLSRQNNYTVNNKRNGVAKVNIFFKE---LNYKTNSESPSVTMVTL 606

  Fly   489 LASFGGIIGLFLGASLLSAFELA-YYFSIGLYLYIHGKRKLRKP--EPG 534
            |::.|....|:.|:|:||..|:| ..|.:.:.:::...|:.|..  .||
Human   607 LSNLGSQWSLWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFRSRYWSPG 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:459966	121/579 (21%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	129/625 (21%)