DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk21 and ASIC4

DIOPT Version :9

Sequence 1:	NP_651704.2	Gene:	ppk21 / 43485	FlyBaseID:	FBgn0039675	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_061144.4	Gene:	ASIC4 / 55515	HGNCID:	21263	Length:	539	Species:	Homo sapiens

Alignment Length:	523	Identity:	119/523 - (22%)
Similarity:	188/523 - (35%)	Gaps:	111/523 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LKDYAAESSVHGIRYLADPKMRNYLNIRVIWLLILLTTSIGAIVVYVDLNELYQTVRIQTTIKNT 112
            |..:|:.|::||:.....|......  |.:|.|.|||:....:.....|...|.| |......:.
Human    42 LATFASTSTLHGLGRACGPGPHGLR--RTLWALALLTSLAAFLYQAAGLARGYLT-RPHLVAMDP 103

  Fly   113 MLPIFRIPFPSIGLCPRNRLNWKILETEAVDHFLGANVSA-AQKDLFVKFFTAAGDPHLS---RL 173
            ..|.....||::.||..||.....|....:.|.  ||::. ..||         .|.|.:   |.
Human   104 AAPAPVAGFPAVTLCNINRFRHSALSDADIFHL--ANLTGLPPKD---------RDGHRAAGLRY 157

  Fly   174 NEMSNFFGNKTLTDELHMLDHLDLREVYKFIQFRCQDLFHTCRWRGNPVNCCEVIEYQ--FTEAG 236
            .|       ..:.|.|:...|            :..|:..:|.:.|:.   |....:.  :|..|
Human   158 PE-------PDMVDILNRTGH------------QLADMLKSCNFSGHH---CSASNFSVVYTRYG 200

  Fly   237 LCFVFNTEISPASRQKAREDKYYPLRTPHYGEGSGLDLFLRLNRSFIRPGKR---------GINV 292
            .|:.||.:  |.|...:|..          |.||||::.|.:.:....|..|         ||.|
Human   201 KCYTFNAD--PRSSLPSRAG----------GMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRV 253

  Fly   293 MIKQPQQWSDVVRHVPHEAHTRISITP---RFTVTDERTRTVTPE-IRRCIFGDEVDNPHYKNFP 353
            .|...::       .|:.......::|   .|....|:..|..|: ...|....|:..|..:.:.
Human   254 QIHSQEE-------PPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGYS 311

  Fly   354 DFEYWVGNCRSRCHQEHVLNLCKCSPSIFFPISDKDNFTACKASDFKCLYDNRFTFSIERHPEED 418
              .|.|..||.||.:|.||..|.|. .:..|    .|.|.|..:.:....|:... |:...||
Human   312 --AYSVSACRLRCEKEAVLQRCHCR-MVHMP----GNETICPPNIYIECADHTLD-SLGGGPE-- 366

  Fly   419 DFVKNPFKESMICDCFTSCSQLVFDRVFTTTTLDN-------------NETDTEAGTMRLDIFYQ 470
                .|      |.|.|.|:...:.:..:...:.|             |||......:.||:|::
Human   367 ----GP------CFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFE 421

  Fly   471 SGWFIQYQTNMRFTFVELLASFGGIIGLFLGASLLSAFE-LAYYFSIGLYLYIHGKRKLRKPEPG 534
            :......:....:....||...||.:|||:|||:|:..| |.|.:.:.   :...||..|:|:..
Human   422 ALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVS---WDRLKRVWRRPKTP 483

  Fly   535 VLT 537
            :.|
Human   484 LRT 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:279230	112/494 (23%)
ASIC4	NP_061144.4	ASC	40..488	CDD:413546	119/523 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7253
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870