DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk21 and ASIC5

DIOPT Version :9

Sequence 1:	NP_651704.2	Gene:	ppk21 / 43485	FlyBaseID:	FBgn0039675	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_059115.1	Gene:	ASIC5 / 51802	HGNCID:	17537	Length:	505	Species:	Homo sapiens

Alignment Length:	518	Identity:	115/518 - (22%)
Similarity:	195/518 - (37%)	Gaps:	133/518 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DYAAESSVHGIRYLAD--PKMRNYLNIRVIWLLILL-TTSIGAIVVYVDLNELYQTVRIQTTIKN 111
            |:|..:|.|||..:..  .|:|     ||:||:::| :.|:....:|:.|.. |.|....|:|:
Human    40 DFAISTSFHGIHNIVQNRSKIR-----RVLWLVVVLGSVSLVTWQIYIRLLN-YFTWPTTTSIE- 97

  Fly   112 TMLPIFRIPFPSIGLCPRNRLNWKILETEAVDHFLGANVSAAQKDLFVKFFTAAGDPHLSRLNEM 176
             :..:.::.||::..|..||     .:|:||..| |.        :|..:...:...||..:.
Human    98 -VQYVEKMEFPAVTFCNLNR-----FQTDAVAKF-GV--------IFFLWHIVSKVLHLQEIT-- 145

  Fly   177 SNFFGNKTLTDELHMLDHLDLREVYKFIQ----FRCQDLFHTCRWRGNPVNCCEVIEYQ--FTEA 235
            :|..|::..||  ....|.:. .:.:||:    :........|.:.|.|   |...::.  |||.
Human   146 ANSTGSREATD--FAASHQNF-SIVEFIRNKGFYLNNSTLLDCEFFGKP---CSPKDFAHVFTEY 204

  Fly   236 GLCFVFNTEISPASRQKAREDKYYPLRTPHYGEGSGLDLFLRLNR---------SFIRPGKRGIN 291
            |.||.||...:..:::|...            .|.||.|...:|:         .|:   ..||.
Human   205 GNCFTFNHGETLQAKRKVSV------------SGRGLSLLFNVNQEAFTDNPALGFV---DAGII 254

  Fly   292 VMIKQPQ---QWSDVVRHVPHEAHTRISITPRFTVTDERTRTVTPEI--RRCIFGDEVDNPHYK- 350
            .:|..|:   |:..:....|...|.|::|        .:.:||..|.  ..|       ||:.|
Human   255 FVIHSPKKVPQFDGLGLLSPVGMHARVTI--------RQVKTVHQEYPWGEC-------NPNIKL 304

  Fly   351 -NFPDFEYWVGNCRSRCHQEHVLNLCKCSPSIF--FPIS-DKDNFTACKASDFKCLYDNRFTFSI 411
             ||.  .|....|...|..:|:...|.|.|.:.  :.|. |...:.:|.:             .:
Human   305 QNFS--SYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVS-------------PV 354

  Fly   412 ERHPEEDDFVKNPFKESMIC-------DCFTSCSQLVFDRV-------------FTTTTLDNNET 456
            ..|.|        ||:  :|       .|..||.::.:...             :.:..|:.:..
Human   355 LDHIE--------FKD--LCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRK 409

  Fly   457 DTEAGTMRLDIFYQSGWFIQYQTNMRFTFVELLASFGGIIGLFLGASLLSAFELAYYFSIGLY 519
            ......::::|.|....:...|.....:..||||..||.:|||.||||::..|:..|.....|
Human   410 YIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFY 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:279230	112/509 (22%)
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	112/509 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820