Protein Alignment ppk21 and asic1b

DIOPT Version :10

• Sequence 1: NP_651704.2
• Gene: ppk21 / 43485
• FlyBaseID: FBgn0039675
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_999956.1
• Gene: asic1b / 407672
• ZFINID: ZDB-GENE-040513-1
• Length: 557
• Species: Danio rerio
• Alignment Length: 524
• Identity: 118/524 - (22%)
• Similarity: 191/524 - (36%)
• Gaps: 150/524 - (28%)

  Fly    56 SVHGIR--YLADPKMRNYLNIRV-IWLLI-LLTTS------IGAIVVYVDLNELYQTVRIQTTIK 110
            |:||..  ::.|.|    .:||. :|.|: ||..|      :..::.|:..:  |.|:..:...|
Zfish    74 SLHGANHVFVEDKK----FSIRQGLWALVFLLAISMFLLQVVDRVIYYLQYD--YVTLLDERNAK 132

  Fly   111 NTMLPIFRIPFPSIGLC-----PRNRLNWKILETEAVDHFLGANVSAAQKDLFVKFFTAAGDPHL 170
            |       :.||:|.||     .|::|::..|      .|:|..:  ..:|........|.:|.
Zfish   133 N-------MTFPAITLCNYNTFRRSQLSYSDL------LFMGPLL--GYEDNMAPGIPLAPEPD- 181

  Fly   171 SRLNEMSNFFGNKTLTDELHMLDHLDLREVYKFIQFRCQDLFHTCRWRGNPVNCCEVIEYQ--FT 233
               .:.|.|                .|.|.:...:.|..|:...|.:.|..   |....::  ||
Zfish   182 ---RQGSRF----------------SLAEFFNRTRHRMDDMLLECNFAGKE---CGAEHWREIFT 224

  Fly   234 EAGLCFVFNTEISPASRQKAREDKYYPLR-TPHYGEGSGLDLFLRLNRSFIRP---------GKR 288
            ..|.|:.||      |.|..|     ||. |...|.|:||::.|.:.:....|         .:.
Zfish   225 RYGKCYTFN------SGQDGR-----PLLITTKGGMGNGLEIMLDIQQDEYLPVWGETDETTFEA 278

  Fly   289 GINVMIKQPQQWSDVVRHVPHEAHTRISITPRF----TVTDERTRTVTPEIRRCIFGD----EVD 345
            ||.|.|....:       .|........:.|.|    :..::|...:.|.     :||    .:|
Zfish   279 GIKVQIHTQDE-------PPFIDQLGFGVAPGFQTFVSCQEQRLTYLPPP-----WGDCKATPID 331

  Fly   346 NPHYKNFPDFEYWVGNCRSRCHQEHVLNLCKCSPSIFFPISDKDNFTACKASDFKCLYDNRFTFS 410
            :..:..     |.:..||..|...:::..|.|. .:..|    .:...|....:|...|....|.
Zfish   332 SDFFNT-----YSITACRIDCETRYLVENCNCR-MVHMP----GDAPYCTPEQYKECADPALDFL 386

  Fly   411 IERHPEEDDFVKNPFKESMICDCFTSCS------QLVFDRV-------FTTTTLDNNETDTEAGT 462
            :||   ::|:          |.|.|.|:      :|.|.|:       :.....:..|.......
Zfish   387 VER---DNDY----------CVCETPCNMTRYGKELSFVRIPSKASAKYLAKKYNKTEQYISDNI 438

  Fly   463 MRLDIFYQSGWFIQYQT---NMRFTFVELLASFGGIIGLFLGASLLSAFELAYYFSIGLYLYIHG 524
            |.||||:::   :.|:|   ...:....||...||.:|||:|||:|:..||   |.   |||...
Zfish   439 MVLDIFFEA---LNYETIEQKKAYELAGLLGDIGGQMGLFIGASILTILEL---FD---YLYEVI 494

  Fly   525 KRKL 528
            |.||
Zfish   495 KFKL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:459966	111/507 (22%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..57
		ENaC	66..548	CDD:273304	118/524 (23%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	477..479		1/1 (100%)