DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk21 and asic1c

DIOPT Version :9

Sequence 1:	NP_651704.2	Gene:	ppk21 / 43485	FlyBaseID:	FBgn0039675	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	XP_021325802.1	Gene:	asic1c / 407670	ZFINID:	ZDB-GENE-040513-3	Length:	562	Species:	Danio rerio

Alignment Length:	584	Identity:	126/584 - (21%)
Similarity:	217/584 - (37%)	Gaps:	145/584 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QRDARKNSRLGKLWHFMLPYLKD----YAAESSVHGIRYLADP-KMRNYLNIRVIWLLILLTTSI 87
            :.:|:..|...||...:...:||    :...:.|||:::...| |.:..   |:.|||.|| ..:
Zfish    14 RHEAQSPSSCRKLKMTLTHNIKDITTAFVLRTKVHGLKHAFSPHKSKTQ---RLFWLLALL-VCL 74

  Fly    88 GAIVVYVDLNELYQTVRIQTTIKNTMLPIFRIPFPSIGLCPRNRLNWKILETEAVDHFLGANVSA 152
            |.:..: ..|.:...:......|..|:....:.||:|..|.:|||....|..:.:.:      |.
Zfish    75 GLLFTW-SWNRILYLLSYPAVTKIYMVWSNNMTFPAITFCNQNRLRVSSLTRDDLYY------SG 132

  Fly   153 AQKDLFVKFFTAAGDPHLSR-LNEMSNFFGNKTLTDE--LHMLD----------HLDLREVYKFI 204
            ...|:.          ||:. ||..|......:...|  ||:||          .|:..|:...:
Zfish   133 YWMDIL----------HLNHTLNRQSVSMLKHSRHRERLLHLLDFSHYSPPPDQSLNTTEMIDRL 187

  Fly   205 QFRCQDLFHTCRWRGNPVNCCEVIEYQ-----FTEAGLCFVFNTEISPASRQKAREDKYYPLRTP 264
            ..:.||:...||:||.  ||    .|:     :|..|.|:.||:.:          |....|.|.
Zfish   188 GHQLQDMLLECRFRGE--NC----TYKNFTPIYTRYGKCYTFNSGL----------DGNPLLTTL 236

  Fly   265 HYGEGSGLDLFLRLNRSFIRPGKRGINVMIKQPQQWSDVVRHVPHEAHTRISI----TPRFTVTD 325
            ..|.|:||::.|.:.:....|             .|.| .....:||..::.|    .|.|  .|
Zfish   237 KGGTGNGLEIMLDIQQDEYLP-------------VWGD-TDETSYEAGIKVQIHSQDEPPF--ID 285

  Fly   326 ERTRTVTPEIRRCI-------------FGD----EVDNPHYKNFPDFEYWVGNCRSRCHQEHVLN 373
            :....|.|..:..:             :||    .:|:.::..     |.:..||..|...::|.
Zfish   286 QLGFGVAPGFQTFVSCQQQLLLYLPPPWGDCRSAPMDSEYFST-----YSITACRIDCETRYLLE 345

  Fly   374 LCKCSPSIFFPISDKDNFTACKASDFKCLYDNRFTFSIERHPEEDDFVKNPFKESMICDCFTSCS 438
            .|.|. .:..|    ...|.|....:|...|....|.:|:   ::|:          |.|.|.|:
Zfish   346 NCNCR-MVHMP----GTSTVCTPEQYKDCADPALDFLVEK---DNDY----------CVCDTPCN 392

  Fly   439 QLVFDRVFTTTTLDN-----------NETD---TEAGTMRLDIFYQSGWFIQYQTNMRFTFVELL 489
            ...:.:..:...:.:           |:|:   |: ..:.||||:::..:.:.:....:....||
Zfish   393 MTRYGKELSMVKIPSKASAKYLAKKFNKTEQYITD-NILVLDIFFEALNYEKIEQKKAYEVAGLL 456

  Fly   490 ASFGGIIGLFLGASLLSAFELAYYFSIGLYLYIHGK------RKLRKPEPGVLTIQFGQRKITP 547
            ...||.:|||:|||:|:..|:..|    ||..:..|      ||.|........:.|.:...:|
Zfish   457 GDIGGQMGLFIGASVLTILEIFDY----LYEVLKDKILGSVLRKRRPHRSASDNLDFSENPTSP 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:279230	111/515 (22%)
asic1c	XP_021325802.1	ASC	34..531	CDD:322155	122/564 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020