Protein Alignment ppk21 and asic4a

DIOPT Version :10

• Sequence 1: NP_651704.2
• Gene: ppk21 / 43485
• FlyBaseID: FBgn0039675
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_999952.1
• Gene: asic4a / 407668
• ZFINID: ZDB-GENE-040513-5
• Length: 539
• Species: Danio rerio
• Alignment Length: 537
• Identity: 120/537 - (22%)
• Similarity: 203/537 - (37%)
• Gaps: 148/537 - (27%)

  Fly    46 PYLKD---YAAESSVHGIRYLADPKMRNYLNIR-VIWLLILLTTSIGAIVVYVDLNELYQTVRIQ 106
            |..||   :|:.||:|||.::.   :...|.:| .:|.|..|.    ::.::     |||..:..
Zfish    36 PPTKDLAGFASASSLHGINHIF---VSGRLGVRQTLWALAFLV----SLALF-----LYQAAKCA 88

  Fly   107 ---------TTIKNTMLPIFRIPFPSIGLCPRNRLNWKILETEAVDHFLGANVSAAQKDLFVKFF 162
                     |.:.....|  .:.||::.:|..||..:..| |:|              |::
Zfish    89 ISYLEHPHVTALNEEATP--EMVFPAVTICNINRFRFSAL-TDA--------------DIY---- 132

  Fly   163 TAAGDPHLSRLNEM--SNFFGNKTLTDELHMLDH--LDLREVYKFIQFRCQDLFHTCRWRGNPVN 223
                  ||:.|..:  .|..|:|. ||    |::  .|:::::.....:.:::..:|.:.|.  |
Zfish   133 ------HLANLTGLPPKNKDGHKP-TD----LEYPAPDMQDIFNRTGHQLEEMLKSCNFSGQ--N 184

  Fly   224 C-CEVIEYQFTEAGLCFVFNTEISPASRQKAREDKYYPLRTPHYGEGSGLDLFLRLNRSFIRP-- 285
            | .|.....:|..|.|:.||     .::..:|       :|...|.|:||::.|.:.:....|
Zfish   185 CSAEDFTVVYTRYGKCYTFN-----GNKTTSR-------KTKQGGMGNGLEIMLDIQQDDYLPIW 237

  Fly   286 -------GKRGINVMIKQPQQWSDVVRHVPHEAHTRISITP---RFTVTDERTRTVTPE-IRRCI 339
                   .:.||.|.|....:       .|:.......::|   .|....|:..|..|: ...|.
Zfish   238 KETNETSLEAGIRVQIHSQDE-------PPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCR 295

  Fly   340 FGDEVDNPHYKNFPDFEYWVGNCRSRCHQEHVLNLCKCSPSIFFPISDKDNFTACKASDFKCLYD 404
            ...|...|.|..     |.:..||.||....||..|||. .:..|    .:...|..||.||: |
Zfish   296 STSEQMIPGYDT-----YSISACRLRCETLEVLRECKCR-MVHMP----GDANICTPSDIKCV-D 349

  Fly   405 NRFTF---------------SIERHPEEDDFVKNPFKESMICDCFTSCSQLVFDRVFTTTTLDNN 454
            .....               ::.|:.:|...||.|.|.|               ..:.:...|.:
Zfish   350 KALALLQKSSGDTCFCETPCNLTRYGKELSMVKIPSKGS---------------ARYLSRKYDKS 399

  Fly   455 ETDTEAGTMRLDIFYQSGWFIQYQT---NMRFTFVELLASFGGIIGLFLGASLLSAFELAYYFSI 516
            |.......:.||||:::   :.|:|   ...:....||...||.:|||:|||:|:..|:..|
Zfish   400 EDYIRDNFLVLDIFFEA---LNYETIEQKKAYDVAGLLGDIGGQMGLFIGASVLTILEILDY--- 458

  Fly   517 GLYLYI-HGKRKLRKPE 532
             :|..| |...:|.:|:
Zfish   459 -VYEVIKHRLERLLRPQ 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:459966	111/507 (22%)
asic4a	NP_999952.1	ENaC	44..472	CDD:273304	116/525 (22%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	446..448		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	474..494		0/1 (0%)