Protein Alignment ppk21 and ASIC2

DIOPT Version :9

• Sequence 1: NP_651704.2
• Gene: ppk21 / 43485
• FlyBaseID: FBgn0039675
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 126/588 - (21%)
• Similarity: 211/588 - (35%)
• Gaps: 166/588 - (28%)

  Fly     4 PLELPRARRPLYRDYGGKSG--LIQTQRDARKNSRLGKLWHFMLPYLKDYAAESSVHGIRYLADP 66
            |..|..|.:|    .||:.|  .:|....||:..          |.|    :.:.:||:|::...
Human    29 PAALAAAGQP----GGGRGGERALQGPGVARRGR----------PSL----SRAKLHGLRHMCAG 75

  Fly    67 KMR--NYLNIRVIWLLILLTTSIGAIVVYVDLNELY-----QTVRIQTTIKNTMLPIFRIPFPSI 124
            :..  .....|.:|:| ...||.|.::.:.....||     ...|:......      ::|||::
Human    76 RTAAGGSFQRRALWVL-AFCTSFGLLLSWSSNRLLYWLSFPSHTRVHREWSR------QLPFPAV 133

  Fly   125 GLCPRNRLNWKIL---ETEAVDHFLGANVSAAQKDLFVKFFTAAGDPHLSRLNEMSNFFGNKTLT 186
            .:|..|.|.:..|   :.....|:||..:........|.......:|......::::|   :...
Human   134 TVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADF---RLFL 195

  Fly   187 DELH-------MLDHLDLREVYKFIQFRCQDLFHTCRWRG---NPVNCCEVIEYQFTEAGLCFVF 241
            ...|       .:|.|.         .:.:|:..:|::||   .|.|...|    ||:.|.|::|
Human   196 PPRHFEGISAAFMDRLG---------HQLEDMLLSCKYRGELCGPHNFSSV----FTKYGKCYMF 247

  Fly   242 NTEISPASRQKAREDKYYPLRTPHYGEGSGLDLFLRLNRSFIRP---------GKRGINVMIKQP 297
            |          :.||....|.|...|.|:||::.|.:.:....|         .:.|:.|.|...
Human   248 N----------SGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQ 302

  Fly   298 QQWSDVVRHVPHEAHTRISITP---RFTVTDERTRTVTP----EIRRCIFGDEVDNPHYKNFPDF 355
            .:       .|........:.|   .|..|.|:..|..|    |.|....|.:.       ||
Human   303 SE-------PPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDF-------FP-- 351

  Fly   356 EYWVGNCRSRCHQEHVLNLCKC---------------------SPSIFFPISDKD-NFTACKASD 398
            .|.:..||..|...:::..|.|                     .|::.. :::|| |:..|:.
Human   352 VYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGL-LAEKDSNYCLCRT-- 413

  Fly   399 FKCLYDNRFTFSIERHPEEDDFVKNPFKESMICDCFTSCSQLVFDRVFTTTTLDNNETDTEAGTM 463
             .|        ::.|:.:|...||.|.|        ||...|  ::.|     :.:|.......:
Human   414 -PC--------NLTRYNKELSMVKIPSK--------TSAKYL--EKKF-----NKSEKYISENIL 454

  Fly   464 RLDIFYQSGWFIQYQT---NMRFTFVELLASFGGIIGLFLGASLLSAFELAYYFSIGLYLYIHGK 525
            .||||:::   :.|:|   ...:....||...||.:|||:|||:|:..||   |.   |:|...|
Human   455 VLDIFFEA---LNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILEL---FD---YIYELIK 510

  Fly   526 RKL 528
            .||
Human   511 EKL 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:279230	108/522 (21%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	114/535 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920