DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk21 and Asic3

DIOPT Version :9

Sequence 1:	NP_651704.2	Gene:	ppk21 / 43485	FlyBaseID:	FBgn0039675	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	XP_038963092.1	Gene:	Asic3 / 286920	RGDID:	708578	Length:	564	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	116/564 - (20%)
Similarity:	193/564 - (34%)	Gaps:	152/564 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KSGLIQTQRDARKNSRLGKLWHFMLPYLKDYAAESSVHGIRYLADP---KMRNYLNIRVIWLLIL 82
            :|||.:.||....:.|:             :|:..::||:.::..|   .:|     |.:|...:
  Rat     4 RSGLEEAQRRQASDIRV-------------FASSCTMHGLGHIFGPGGLTLR-----RGLWATAV 50

  Fly    83 LTTSIGAIVVYVDLNELYQTVRIQTTIKNTMLPIFRIPFPSIGLCPRNRLNWKILETEAVDHFLG 147
            |.:....:....:....|.....:||:...  ...::.||::.||..|.|....|....: |:.|
  Rat    51 LLSLAAFLYQVAERVRYYGEFHHKTTLDER--ESHQLTFPAVTLCNINPLRRSRLTPNDL-HWAG 112

  Fly   148 ANVSAAQKDLFVKFFTAAGDPHLSRLNEMSNFFGNKTLTDELHMLDHLDLREVYKFIQFRCQDLF 212
            ..:..........:..|.|.|...     ..|..:.|          .|:.::|.......:|:.
  Rat   113 TALLGLDPAEHAAYLRALGQPPAP-----PGFMPSPT----------FDMAQLYARAGHSLEDML 162

  Fly   213 HTCRWRGNPVNCC--EVIEYQFTEAGLCFVFNTEISPASRQKAREDKYYPLRTPHYGEGSGLDLF 275
            ..||:||.|   |  |.....||..|.|:.||:....|..          |.||..|.|:||::.
  Rat   163 LDCRYRGQP---CGPENFTVIFTRMGQCYTFNSGAHGAEL----------LTTPKGGAGNGLEIM 214

  Fly   276 LRLNRSFIRPGKRGINVMIKQPQQWSDVVRHVPHEAHTRISITPRFTVTDERTRTVTPEIRRCIF 340
            |.:.:....|             .|.| :...|.|...|:.|..:    ||     .|.|.:..|
  Rat   215 LDVQQEEYLP-------------IWKD-MEETPFEVGIRVQIHSQ----DE-----PPAIDQLGF 256

  Fly   341 G-----------------------------------------DEVDNPHYKNFPDFEYWVGNCRS 364
            |                                         |.:.:|..:..|.:.. :| ||.
  Rat   257 GAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSL-IG-CRL 319

  Fly   365 RCHQEHVLNLCKCSPSIFFPISDKDNFTACKASDFK-CLYDNRFTFSIERHPEEDDFVKNPFKES 428
            .|...:|...|.|. .:..|    .|...|....:| |           ..|..|..::   |::
  Rat   320 ACESRYVARKCGCR-MMHMP----GNSPVCSPQQYKDC-----------ASPALDAMLR---KDT 365

  Fly   429 MIC--DCFTS--CSQLVFDRV-------FTTTTLDNNETDTEAGTMRLDIFYQSGWFIQYQTNMR 482
            .:|  .|.|:  ..:|...|:       :.....:.:|:......:.||||:::..:...:....
  Rat   366 CVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAA 430

  Fly   483 FTFVELLASFGGIIGLFLGASLLSAFE-LAYYFSIGLYLYIHGK 525
            :...|||...||.:|||:|||||:..| |.|...:|.....||:
  Rat   431 YEVSELLGDIGGQMGLFIGASLLTILEILDYLCEVGKNPRHHGE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:279230	106/520 (20%)
Asic3	XP_038963092.1	ASC	17..547	CDD:413546	111/551 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920