DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk21 and Asic2

DIOPT Version :9

Sequence 1:	NP_651704.2	Gene:	ppk21 / 43485	FlyBaseID:	FBgn0039675	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_037024.2	Gene:	Asic2 / 25364	RGDID:	2017	Length:	563	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	127/588 - (21%)
Similarity:	214/588 - (36%)	Gaps:	166/588 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PLELPRARRPLYRDYGGKSG--LIQTQRDARKNSRLGKLWHFMLPYLKDYAAESSVHGIRYLADP 66
            |:.:..||:|    .|.:||  .:|....||:..          |.|    :.:.:||:|::...
  Rat    29 PVAVAAARQP----GGDRSGDPALQGPGVARRGR----------PSL----SRTKLHGLRHMCAG 75

  Fly    67 KMR--NYLNIRVIWLLILLTTSIGAIVVYVDLNELY-----QTVRIQTTIKNTMLPIFRIPFPSI 124
            :..  .....|.:|:| ...||:|.::.:.....||     ...|:......      ::|||::
  Rat    76 RTAAGGSFQRRALWVL-AFCTSLGLLLSWSSNRLLYWLSFPSHTRVHREWSR------QLPFPAV 133

  Fly   125 GLCPRNRLNWKIL---ETEAVDHFLGANVSAAQKDLFVKFFTAAGDPHLSRLNEMSNFFGNKTLT 186
            .:|..|.|.:..|   :.....|:||..:........|.......:|......::::|   :...
  Rat   134 TVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADF---RLFL 195

  Fly   187 DELH-------MLDHLDLREVYKFIQFRCQDLFHTCRWRG---NPVNCCEVIEYQFTEAGLCFVF 241
            ...|       .:|.|.         .:.:|:..:|::||   .|.|...|    ||:.|.|::|
  Rat   196 PPRHFEGISAAFMDRLG---------HQLEDMLLSCKYRGELCGPHNFSSV----FTKYGKCYMF 247

  Fly   242 NTEISPASRQKAREDKYYPLRTPHYGEGSGLDLFLRLNRSFIRP---------GKRGINVMIKQP 297
            |          :.||....|.|...|.|:||::.|.:.:....|         .:.|:.|.|...
  Rat   248 N----------SGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQ 302

  Fly   298 QQWSDVVRHVPHEAHTRISITP---RFTVTDERTRTVTP----EIRRCIFGDEVDNPHYKNFPDF 355
            .:       .|........:.|   .|..|.|:..|..|    |.|....|.:.       ||
  Rat   303 SE-------PPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDF-------FP-- 351

  Fly   356 EYWVGNCRSRCHQEHVLNLCKC---------------------SPSIFFPISDKD-NFTACKASD 398
            .|.:..||..|...:::..|.|                     .|::.. :::|| |:..|:.
  Rat   352 VYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGL-LAEKDSNYCLCRT-- 413

  Fly   399 FKCLYDNRFTFSIERHPEEDDFVKNPFKESMICDCFTSCSQLVFDRVFTTTTLDNNETDTEAGTM 463
             .|        ::.|:.:|...||.|.|        ||...|  ::.|     :.:|.......:
  Rat   414 -PC--------NLTRYNKELSMVKIPSK--------TSAKYL--EKKF-----NKSEKYISENIL 454

  Fly   464 RLDIFYQSGWFIQYQT---NMRFTFVELLASFGGIIGLFLGASLLSAFELAYYFSIGLYLYIHGK 525
            .||||:::   :.|:|   ...:....||...||.:|||:|||||:..||   |.   |:|...|
  Rat   455 VLDIFFEA---LNYETIEQKKAYEVAALLGDIGGQMGLFIGASLLTILEL---FD---YIYELIK 510

  Fly   526 RKL 528
            .||
  Rat   511 EKL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:279230	109/522 (21%)
Asic2	NP_037024.2	ENaC	64..557	CDD:273304	115/535 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020