Protein Alignment ppk21 and Scnn1a

DIOPT Version :10

• Sequence 1: NP_651704.2
• Gene: ppk21 / 43485
• FlyBaseID: FBgn0039675
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_113736.1
• Gene: Scnn1a / 25122
• RGDID: 3639
• Length: 699
• Species: Rattus norvegicus
• Alignment Length: 612
• Identity: 126/612 - (20%)
• Similarity: 204/612 - (33%)
• Gaps: 205/612 - (33%)

  Fly    21 KSGLIQTQRDARKNSRLGKLWHFMLPYLKDYAAESSVHG-IRYLADP--KMRNYLNIRVIWLLIL 82
            :..||:..|..|      :|:.|       :...:::|| ||.:...  :|:.     ..|.::.
  Rat    71 EEALIEFHRSYR------ELFQF-------FCNNTTIHGAIRLVCSKHNRMKT-----AFWAVLW 117

  Fly    83 LTTSIGAIVVYVDLNELYQTVRIQTTIKNTMLPIFRIPFPSIGLCPRNRLNWKIL--ETEAVDHF 145
            |.| .|  ::|.....|::.........|..|...::.||::.:|..|...:..:  |.|.:|..
  Rat   118 LCT-FG--MMYWQFALLFEEYLSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEELEELDRI 179

  Fly   146 ------------------LGANVSAAQKDLFVKFFTAAGDPH-LSRLNEMSNFF-------GNKT 184
                              .||. ..:.:||...|      || |.||......:       |:.:
  Rat   180 TEQTLFDLYKYNSSYTRQAGAR-RRSSRDLLGAF------PHPLQRLRTPPPPYSGRTARSGSSS 237

  Fly   185 LTDELHMLDHLD--------------------------LREVYKF----IQFRCQD--------- 210
            :.|....:|..|                          :||.|:|    |..|..|
  Rat   238 VRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLSDTSPALEEEA 302

  Fly   211 ---LFHTCRWRGNPVNCCEVIEYQFTEAGLCFVFNTEISPASRQKAREDKYYPLRTPHYGEGSGL 272
               ...|||:...|.|.....::.....|.|:.||.:         .....:....|  |..:||
  Rat   303 LGNFIFTCRFNQAPCNQANYSKFHHPMYGNCYTFNDK---------NNSNLWMSSMP--GVNNGL 356

  Fly   273 DLFLRLNRSFIRP---GKRGINVMIKQPQQWSDVVRHVPHEAHTRISITPRFTVTDERTRTVTPE 334
            .|.||..::...|   ...|..||:           |...|        |.|  .|:....:.|.
  Rat   357 SLTLRTEQNDFIPLLSTVTGARVMV-----------HGQDE--------PAF--MDDGGFNLRPG 400

  Fly   335 IRRCI-------------FGDEVDNPH---YKNFPDFEYWVGNCRSRCHQEHVLNLCKCSPSIFF 383
            :...|             :||..:|..   .||....:|....|...|.||:::..|.|: .||:
  Rat   401 VETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCA-YIFY 464

  Fly   384 PISDKDNFTACKASDFK-------CLYDNRFTFSIERHPEEDDFVKNPFKESMIC--DCFTSCSQ 439
            |......|  |   |::       |.|..:..||:               :|:.|  .|...||.
  Rat   465 PKPKGVEF--C---DYRKQSSWGYCYYKLQGAFSL---------------DSLGCFSKCRKPCSV 509

  Fly   440 LVF---------------DRVFTTTTLDNNET--DTEAGTMRLDIFYQSGWFIQYQTNMR---FT 484
            :.:               |.:|...:|.||.|  :...|..:|:||::.   :.|:||..   .|
  Rat   510 INYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKE---LNYKTNSESPSVT 571

  Fly   485 FVELLASFGGIIGLFLGASLLSAFELA 511
            .|.||::.|....|:.|:|:||..|:|
  Rat   572 MVSLLSNLGSQWSLWFGSSVLSVVEMA 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk21	NP_651704.2	ASC	51..513	CDD:459966	120/582 (21%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	123/603 (20%)