DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk21 and Scnn1b

DIOPT Version :10

Sequence 1:NP_651704.2 Gene:ppk21 / 43485 FlyBaseID:FBgn0039675 Length:550 Species:Drosophila melanogaster
Sequence 2:NP_035455.1 Gene:Scnn1b / 20277 MGIID:104696 Length:638 Species:Mus musculus


Alignment Length:412 Identity:80/412 - (19%)
Similarity:140/412 - (33%) Gaps:100/412 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   176 MSNFFGNKTLTDELHMLDHLDLREVYKFIQFRCQDL----------FHTCRWRGNPVNCCEVIEY 230
            :.||........|.::|...::     |.|...|||          ...|.:...|.:.......
Mouse   203 LRNFTSATQAVTEWYILQATNI-----FSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPI 262

  Fly   231 QFTEAGLCFVFNTEISPASRQKAREDKYYPLR----------TPHYGEGSGLDLFLRLNRS--FI 283
            .:.:.|.|::||..::..:...|.....:.|:          .|.....:|..|.|...|:  ||
Mouse   263 FYPDYGNCYIFNWGMTEETLPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLMLHEQRTYPFI 327

  Fly   284 RPGKRGINVMIKQPQQWSDVVRHVPHEAHTRISITPRFTVTDERTRTVTPEIRRCIFGDEVDNPH 348
            |  :.||..|                 |.|..||.   .:.|:..|...|.....:.|.:|...:
Mouse   328 R--EEGIYAM-----------------AGTETSIG---VLVDKLQRKGEPYSPCTMNGSDVAIKN 370

  Fly   349 YKNFPDFEYWVGNCRSRCHQEHVLNLCKCSPSIFFPISDKDNFTACKASDFK----CLYDNRFTF 409
            ..:..:..|.:..|...|.|:|::..|.|. ...:|:.:.:.:  |...||.    | |.| ...
Mouse   371 LYSVYNTTYSIQACLHSCFQDHMIRNCSCG-HYLYPLPEGEKY--CNNRDFPDWAYC-YLN-LQM 430

  Fly   410 SIERHPEEDDFVKNPFKESMICDCFTSCSQLVFDRVFTTTTLD---------------------N 453
            |:.:            :|:.:..|..||:...:.  .|.:..|                     :
Mouse   431 SVTQ------------RETCLSMCKESCNDTQYK--MTISMADWPSEASEDWILHVLSQERDQSS 481

  Fly   454 NETDTEAGTMRLDIFYQSGWFIQYQTNMRFTFVELLASFGGIIGLFLGASLLSAFELA------- 511
            |.|.:..|.::|:|::|...:...:.:.....|.||::.||..|.::|.|:|...|..       
Mouse   482 NITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFI 546

  Fly   512 YYFSIGLYLYIHGKRKLRKPEP 533
            :...|.|.....|.|:.|...|
Mouse   547 WITIIKLVASCKGLRRRRPQAP 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk21NP_651704.2 ASC 51..513 CDD:459966 74/390 (19%)
Scnn1bNP_035455.1 ENaC 21..621 CDD:273304 80/412 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 594..620
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51168 614..618
Blue background indicates that the domain is not in the aligned region.

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