Protein Alignment Dop1R2 and TAAR8

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_444508.1
• Gene: TAAR8 / 83551
• HGNCID: 14964
• Length: 342
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 105/396 - (26%)
• Similarity: 162/396 - (40%)
• Gaps: 109/396 - (27%)

  Fly   105 PNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYE 169
            |..||.|.......|...||||.||:.:|:..:.||:.||:.|.|||.||.|||:.||.|| :..
Human    28 PGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFKQLHSPTNFLIASLACADFLVGVTVMLFS-MVR 91

  Fly   170 VLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVW 234
            .:|:.|:||..:|.:....||.|..:|:|:||.|.:|||..:|||..|..:.||..:...|:..|
Human    92 TVESCWYFGAKFCTLHSCCDVAFCYSSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSW 156

  Fly   235 ICSSAISFPAIVWWRAARDGEMPAY--------KCTFTEHLGYLVFSSTISFYLPLLVMVFTYCR 291
            |.  .:::...|::....|..:...        .|......|:::....: |::|.|||:..|.:
Human   157 IL--PLTYSGAVFYTGVNDDGLEELVSALNCVGGCQIIVSQGWVLIDFLL-FFIPTLVMIILYSK 218

  Fly   292 IYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHS 356
            |:  .:.:.:::||
Human   219 IF--LIAKQQAIKI--------------------------------------------------- 230

  Fly   357 HSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTL 421
                          .|||:..|...|                      |.|:....:|:||||||
Human   231 --------------ETTSSKVESSSE----------------------SYKIRVAKRERKAAKTL 259

  Fly   422 GIVMGVFIICWLPFFV---VNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRR 483
            |:.:..|:|.|||:.|   ::...||......:|     |..|..:.||.|||:|||.:...||:
Human   260 GVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYE-----ICCWSAYYNSAMNPLIYALFYPWFRK 319

  Fly   484 AFVRLL 489
            |...:|
Human   320 AIKLIL 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	98/373 (26%)
		TM helix 2	143..169	CDD:320195	15/25 (60%)
		TM helix 3	182..212	CDD:320195	12/29 (41%)
		TM helix 4	224..246	CDD:320195	3/21 (14%)
		TM helix 5	266..295	CDD:320195	8/28 (29%)
		TM helix 6	297..442	CDD:320195	23/147 (16%)
		TM helix 7	453..478	CDD:320195	10/24 (42%)
TAAR8	NP_444508.1	7tmA_TAAR6_8_9	32..321	CDD:320439	101/386 (26%)
		TM helix 1	33..59	CDD:320439	9/25 (36%)
		TM helix 2	66..92	CDD:320439	15/26 (58%)
		TM helix 3	104..134	CDD:320439	12/29 (41%)
		TM helix 4	146..169	CDD:320439	4/24 (17%)
		TM helix 5	193..222	CDD:320439	8/31 (26%)
		TM helix 6	250..280	CDD:320439	14/29 (48%)
		TM helix 7	289..314	CDD:320439	11/29 (38%)