Protein Alignment Dop1R2 and htr1ab

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001139238.1
• Gene: htr1ab / 797538
• ZFINID: ZDB-GENE-090409-2
• Length: 403
• Species: Danio rerio
• Alignment Length: 400
• Identity: 142/400 - (35%)
• Similarity: 211/400 - (52%)
• Gaps: 56/400 - (14%)

  Fly   111 LLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTW 175
            |:..|.|.|   :|||:.|:.|:..||.|....||.|.||||.|.:|.::|:|.:|||:||:. |
Zfish    41 LIGALILCS---IFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLDK-W 101

  Fly   176 FFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAI 240
            ..|...|||:.|||:|..|:|||:||.|:||||||||||..|..:.|:||||.||...|....:|
Zfish   102 TLGQVTCDIFISLDILCCTSSILHLCAIALDRYWAITDPIDYMKKRTLKRAALLITVTWFVGFSI 166

  Fly   241 SFPAIVWWRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRS--- 302
            |.|.::..::     .|. .|..:....|.::|:..:||:||::|:..|.||::||..:.|.
Zfish   167 SIPPMLIMKS-----QPK-TCMISHDPWYTIYSTFCAFYIPLILMLVLYGRIFKAARFRIRKTVR 225

  Fly   303 ---------LKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGG----GGGGGSLS 354
                     |.:.......|:|||           :::.::.|.........|    ...|.||.
Zfish   226 KPEKKRVKCLTVSPALFKRANGEL-----------SKNWKSAVEPKPAACVNGAIKHAEDGESLE 279

  Fly   355 HSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAK 419
            ....||:..::       ...|..|:..|        |..::| .||....|||| .|:|:|..|
Zfish   280 IIEVHSNSKNN-------LPLPNTPNSVP--------LFENKH-EKNTEAKRKLA-LARERKTVK 327

  Fly   420 TLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRA 484
            ||||:||.||:||||||:..|:..||..|: ....:..::.|||:.||.:||:|||.:::||:.|
Zfish   328 TLGIIMGTFILCWLPFFIKALVMPFCPTCV-MPLWLQDVINWLGYSNSLLNPIIYAYFNKDFQSA 391

  Fly   485 FVRLL-CMCC 493
            |.::: |..|
Zfish   392 FKKIIKCHFC 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	134/378 (35%)
		TM helix 2	143..169	CDD:320195	13/25 (52%)
		TM helix 3	182..212	CDD:320195	20/29 (69%)
		TM helix 4	224..246	CDD:320195	10/21 (48%)
		TM helix 5	266..295	CDD:320195	10/28 (36%)
		TM helix 6	297..442	CDD:320195	43/160 (27%)
		TM helix 7	453..478	CDD:320195	10/24 (42%)
htr1ab	NP_001139238.1	7tm_GPCRs	36..392	CDD:475119	138/389 (35%)
		TM helix 1	38..62	CDD:320453	9/23 (39%)
		TM helix 2	71..93	CDD:320453	11/21 (52%)
		TM helix 3	109..131	CDD:320453	13/21 (62%)
		TM helix 4	154..170	CDD:320453	5/15 (33%)
		TM helix 5	187..210	CDD:320453	7/22 (32%)
		TM helix 6	326..348	CDD:320453	15/21 (71%)
		TM helix 7	360..385	CDD:320453	10/24 (42%)