Protein Alignment Dop1R2 and Htr5b

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_077371.1
• Gene: Htr5b / 79247
• RGDID: 62388
• Length: 370
• Species: Rattus norvegicus
• Alignment Length: 432
• Identity: 121/432 - (28%)
• Similarity: 186/432 - (43%)
• Gaps: 85/432 - (19%)

  Fly    60 PTSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVF 124
            |...|...::.:|..|...:|     ||...:..||..|.|       .|.::..|.|...||..
  Rat    16 PPGPESCSDSPSSGRSMGSTP-----GGLILSGREPPFSAF-------TVLVVTLLVLLIAATFL 68

  Fly   125 GNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEV-LENTWFFGTDWCDIWRSL 188
            .|.||::.::|.|..|...:..:.|.||:|.||..:|||.|.:.|: ....|..|...|.:|.|.
  Rat    69 WNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWQLGRSLCHVWISF 133

  Fly   189 DVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISF-PAIVWWRAAR 252
            |||..||||.|:..|:|||||.||....|.:|...:.:|.:||..|..|:.|:. |.:..|..|.
  Rat   134 DVLCCTASIWNVAAIALDRYWTITRHLQYTLRTRRRASALMIAITWALSALIALAPLLFGWGEAY 198

  Fly   253 DGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGEL 317
            |..:  .:|..::...|.|||:..:||:||.|::|.|.:||:||     ..:.|.::..:....
  Rat   199 DARL--QRCQVSQEPSYAVFSTCGAFYVPLAVVLFVYWKIYKAA-----KFRFGRRRRAVVPLP- 255

  Fly   318 QLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEP-DD 381
                                                                 .||...|.| :.
  Rat   256 -----------------------------------------------------ATTQAKEAPQES 267

  Fly   382 EPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCI 446
            |.:...........:..|.::       :..|||:||..:||::|||::||:|||:..|:|..|
  Rat   268 ETVFTARCRATVAFQTSGDSW-------REQKEKRAAMMVGILIGVFVLCWIPFFLTELVSPLC- 324

  Fly   447 ECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRL 488
             ......|..:|..|||:.||..||:||..:::::..||..|
  Rat   325 -ACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSL 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	103/365 (28%)
		TM helix 2	143..169	CDD:320195	10/25 (40%)
		TM helix 3	182..212	CDD:320195	17/29 (59%)
		TM helix 4	224..246	CDD:320195	7/22 (32%)
		TM helix 5	266..295	CDD:320195	13/28 (46%)
		TM helix 6	297..442	CDD:320195	23/145 (16%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)
Htr5b	NP_077371.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		4/19 (21%)
		7tmA_5-HT5	63..362	CDD:320451	104/368 (28%)
		TM helix 2	87..113	CDD:320451	10/25 (40%)
		TM helix 3	127..157	CDD:320451	17/29 (59%)
		TM helix 4	169..190	CDD:320451	6/20 (30%)
		TM helix 5	210..239	CDD:320451	13/28 (46%)
		TM helix 6	291..321	CDD:320451	16/29 (55%)
		TM helix 7	330..355	CDD:320451	11/24 (46%)