Protein Alignment Dop1R2 and htr2b

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001038208.1
• Gene: htr2b / 751784
• ZFINID: ZDB-GENE-081022-57
• Length: 443
• Species: Danio rerio
• Alignment Length: 459
• Identity: 130/459 - (28%)
• Similarity: 205/459 - (44%)
• Gaps: 110/459 - (23%)

  Fly   105 PNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYE 169
            |:....||..|.:  ..|:.||.||||||..||.|..|||:|:.||||||.||||:|||.:.:..
Zfish    13 PSHWAALLILLVI--VPTIGGNILVILAVSLERKLQNATNFFLMSLAVADLLVGLLVMPIALVTV 75

  Fly   170 VLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVW 234
            :..:||......|.||..||||||||||::||.||||||.||..|..:....:..:....||.||
Zfish    76 LYNSTWPLADFLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQHSQFKSRAKVLAKIALVW 140

  Fly   235 ICSSAISFPAIVWWRAARDGEMPAYKCTFTEH------------------LGYLVFSSTISFYLP 281
            :.|..|:.|            :|.....|.:|                  ..:.|:.|.::|::|
Zfish   141 LISIGIAIP------------IPIKGLQFFDHPNITFNKNHTCLLSPEGFRDFKVYGSLVAFFIP 193

  Fly   282 LLVMVFTY---CRIYR--AAVIQTRSLKIGTKQV------LMASGELQLTLRIHRGGTTRDQQNQ 335
            |.:|:..|   .::.|  |.::::|:.:.....|      ::||.|..    :...|..||:
Zfish   194 LAIMMIIYLLTIQVLRKKAYLLRSRAARPSISTVFQQELSVLASPEKM----VISNGIKRDR--- 251

  Fly   336 VSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEP---DDEPLSALHNNGLARHRH 397
                                                 |..|..|   |:.||..:...|
Zfish   252 -------------------------------------TLNPVNPITGDEVPLRRMSTIG------ 273

  Fly   398 MGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEH--EEIVSAIVT 460
                   .|.:.....|::|:|.||||..:|::.|.|||:.|:.|..|..|..:  ::::. |..
Zfish   274 -------KRSMQNLTNEQRASKVLGIVFMLFVVMWCPFFITNVTSVLCERCNGNLVDQLLD-IFQ 330

  Fly   461 WLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKIRRKYQPTMRSKSQCHVAAAMVAASTSFG 525
            |:|:::|.:||::|..::|.||.||.|.: .|..:.:|   .|.::.:|:....:::...|..|.
Zfish   331 WVGYVSSGINPLVYTLFNRTFRLAFRRYI-TCNYKSVR---TPKLQRRSKISFRSSVTENSKRFM 391

  Fly   526 YHSV 529
            .|.:
Zfish   392 KHGM 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	116/396 (29%)
		TM helix 2	143..169	CDD:320195	16/25 (64%)
		TM helix 3	182..212	CDD:320195	22/29 (76%)
		TM helix 4	224..246	CDD:320195	7/21 (33%)
		TM helix 5	266..295	CDD:320195	9/51 (18%)
		TM helix 6	297..442	CDD:320195	29/153 (19%)
		TM helix 7	453..478	CDD:320195	7/24 (29%)
htr2b	NP_001038208.1	7tm_GPCRs	15..362	CDD:475119	122/419 (29%)
		TM helix 1	17..41	CDD:410628	12/25 (48%)
		TM helix 2	50..72	CDD:410628	15/21 (71%)
		TM helix 3	89..111	CDD:410628	15/21 (71%)
		TM helix 4	134..150	CDD:410628	7/27 (26%)
		TM helix 5	179..202	CDD:410628	6/22 (27%)
		TM helix 6	287..309	CDD:410628	10/21 (48%)
		TM helix 7	323..348	CDD:410628	7/25 (28%)