DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R2 and Htr7

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_038945768.1	Gene:	Htr7 / 65032	RGDID:	71034	Length:	508	Species:	Rattus norvegicus

Alignment Length:	413	Identity:	125/413 - (30%)
Similarity:	197/413 - (47%)	Gaps:	102/413 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 DRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVL 171
            ::|.:.:.|.|.:..|:.||.||:::|...:.|...:||.|.|||:||..|.:.||||.::.:::
  Rat    83 EKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLI 147

  Fly   172 ENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWIC 236
            ...|.||..:|:::.::||:..||||:.|||||:|||..||.|.:||:|...|..|.:|.:||:.
  Rat   148 GGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLL 212

  Fly   237 SSAISFPAIVWW-RAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQT 300
            |::|:.|.:..| :...|.::    |..::..||.::|:.::||:|:.||:|.|.:||:||
  Rat   213 SASITLPPLFGWAQNVNDDKV----CLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAA---- 269

  Fly   301 RSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHH 365
                                                                   ..|.:.|
  Rat   270 -------------------------------------------------------RKSAAKH--- 276

  Fly   366 NHGGGTTTSTPEEPDDEPLSALHNNGLAR--------------HRHMGKNFSLSRKLAKFAKEKK 416
                    ..|..|..:|.|.:..||:.:              .:|..||.|:      |.:|:|
  Rat   277 --------KFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISI------FKREQK 327

  Fly   417 AAKTLGIVMGVFIICWLPFFVVN----LLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACW 477
            ||.||||::|.|.:||||||:::    .:.|....||  ...|.....|||:.||.:||.|||.:
  Rat   328 AATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCI--PLWVERTCLWLGYANSLINPFIYAFF 390

  Fly   478 SRDFRRAFVRLLCMCCPRKIRRK 500
            :||.|..: |.|..|..|.|.||
  Rat   391 NRDLRTTY-RSLLQCQYRNINRK 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	66/172 (38%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	108/367 (29%)
Htr7	XP_038945768.1	7tmA_5-HT7	100..398	CDD:320452	114/379 (30%)
		TM helix 2	120..142	CDD:320452	13/21 (62%)
		TM helix 3	159..181	CDD:320452	10/21 (48%)
		TM helix 4	204..220	CDD:320452	5/15 (33%)
		TM helix 5	240..263	CDD:320452	9/22 (41%)
		TM helix 6	329..351	CDD:320452	13/21 (62%)
		TM helix 7	366..391	CDD:320452	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.870