Protein Alignment Dop1R2 and Htr6

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_077341.2
• Gene: Htr6 / 64354
• RGDID: 62044
• Length: 438
• Species: Rattus norvegicus
• Alignment Length: 457
• Identity: 139/457 - (30%)
• Similarity: 196/457 - (42%)
• Gaps: 112/457 - (24%)

  Fly    67 LNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVIL 131
            :|::|.|......|   |.||.|                    .:.|.|.:....|...|||:|:
  Rat     8 VNSSTPAWGPGPPP---APGGSG--------------------WVAAALCVVIVLTAAANSLLIV 49

  Fly   132 AVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTAS 196
            .:..:..|...:|:|:.||..:|.:||||||| .|:...|...|......|.:|.:.||:..:||
  Rat    50 LICTQPALRNTSNFFLVSLFTSDLMVGLVVMP-PAMLNALYGRWVLARGLCLLWTAFDVMCCSAS 113

  Fly   197 ILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISF-PAIVWWRAARDGEMPA-Y 259
            |||||:||||||..|..|..|.:|||..||..||...|..::..|| |.::.|........|| .
  Rat   114 ILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPG 178

  Fly   260 KCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAA---VIQTRSLKIGTKQVLMASGELQLTL 321
            :|.....|.:::.:|.::|:||...:.||||||..||   .:|..||..||      :|:...||
  Rat   179 QCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGT------AGQALETL 237

  Fly   322 RIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTP--EEPDDEPL 384
            ::.|                                               |..|  |..|...|
  Rat   238 QVPR-----------------------------------------------TPRPGMESADSRRL 255

  Fly   385 SALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECI 449
            :..|:.                      |..||:.||||::|:|.:.||||||.|:....| :||
  Rat   256 ATKHSR----------------------KALKASLTLGILLGMFFVTWLPFFVANIAQAVC-DCI 297

  Fly   450 EHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLL-CMCCPRKIRRKYQPTMRSKSQCHV 513
            ...  :..::||||:.||.|||:||..:.|||:||..|.| |:.||.:.|.  .|...|....|.
  Rat   298 SPG--LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRA--SPASPSMWTSHS 358

  Fly   514 AA 515
            .|
  Rat   359 GA 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	118/369 (32%)
		TM helix 2	143..169	CDD:320195	13/25 (52%)
		TM helix 3	182..212	CDD:320195	17/29 (59%)
		TM helix 4	224..246	CDD:320195	8/22 (36%)
		TM helix 5	266..295	CDD:320195	11/28 (39%)
		TM helix 6	297..442	CDD:320195	31/146 (21%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)
Htr6	NP_077341.2	7tmA_5-HT6	29..331	CDD:320182	120/380 (32%)
		TM helix 1	29..54	CDD:320182	7/24 (29%)
		TM helix 2	61..87	CDD:320182	13/26 (50%)
		TM helix 3	99..129	CDD:320182	17/29 (59%)
		TM helix 4	141..164	CDD:320182	8/22 (36%)
		TM helix 5	185..214	CDD:320182	11/28 (39%)
		TM helix 6	261..291	CDD:320182	16/51 (31%)
		TM helix 7	299..324	CDD:320182	11/26 (42%)