Protein Alignment Dop1R2 and 5-HT2B

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_061501050.1
• Gene: 5-HT2B / 5667641
• VectorBaseID: AGAMI1_004218
• Length: 908
• Species: Anopheles gambiae
• Alignment Length: 821
• Identity: 195/821 - (23%)
• Similarity: 304/821 - (37%)
• Gaps: 212/821 - (25%)

  Fly     8 SPEVEGAEG---AGAPLLALLRVDGLNQTQTRSPSPSFFGSYNISEDVYFYFNGLPTSTELVLNA 69
            ||.:.|...   |||.:...:|  ||.....|.|:.:.:.||.    ..|.|.|.|....
Mosquito    34 SPHLSGTATVTLAGATVGVGVR--GLAGGLVRPPAYTGYVSYM----KQFNFTGNPIDNR----- 87

  Fly    70 TTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVI 134
              :...|.|.|..:     .....|.|.|..  ||.| ...|||.:.:  |.|..||.||.||::
Mosquito    88 --TGAEAGLGPDRI-----DADDDEDDGSSL--ALHN-YWALLAIILV--FGTAAGNILVCLAIV 140

  Fly   135 RERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILN 199
            .||.|...||||:.|||:.|.:|.|.|||...| .:::..:...:::|.:|..|||||.||||::
Mosquito   141 WERRLQNVTNYFLMSLAITDLMVALSVMPLGIL-TLVKGHFPLDSEYCLVWICLDVLFCTASIMH 204

  Fly   200 LCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYKCTFT 264
            ||.||:|||.::..|..:....|.:|....|:.||:.|.|:|.|..:.:.......:....|...
Mosquito   205 LCTISVDRYLSLRYPMKFGRNKTRRRVVLKISFVWLLSIAMSLPLSLMYSKNHASVLVDGTCQIP 269

  Fly   265 EHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTT 329
            :.: |.:..|.:.||:||.||:.||                            .||:|:
Mosquito   270 DPV-YKLVGSIVCFYIPLCVMLITY----------------------------TLTVRL------ 299

  Fly   330 RDQQNQVSGGGGGGGGGGGG--GGS--------------LSHSHSHSHHHH------------HN 366
            ..||::..||.|.|||...|  |.:              ||...:.:.|.|            .|
Mosquito   300 LAQQSENLGGVGSGGGWSSGWLGQAPAFDRRNTWKRIIKLSLPAAQNPHAHSAASTDTELSTLDN 364

  Fly   367 HGGGTTTSTPEEPDDEPLSALHNNG------------LARH--RHMGKNFSL-----SRKLAKFA 412
            |......|:..||....::|:...|            :|:|  |:.|:|.|.     ||:...|.
Mosquito   365 HDLWLLESSIPEPSSITMTAMQRFGEEMLKLSQGLESVAQHSDRNSGQNGSSRSPEPSREKESFR 429

  Fly   413 KEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACW 477
            |:...||...          .|..:|.:.|.     :..::..|:..||:...||...|.:
Mosquito   430 KKPANAKHAP----------TPVTMVTVRSP-----VPSKKRRSSTSTWIARRNSGTPPPV---- 475

  Fly   478 SRDFRRAFVRLLCMCCPRKIRRKYQPTMRSKSQCHVAAAMVAASTSFGYHSVNQIDRTLMXRQLS 542
                             |.:|:::      ||..|  |....||...      ::|...|...|.
Mosquito   476 -----------------RLVRKRF------KSLPH--ALPPPASDDI------EVDEQFMQDVLY 509

  Fly   543 SCSTCSGGSNCGGSRSAHHQHHSSGTA----TPSSSQRSCTRCQSFHRHHHRSRRRSSGMQMRGD 603
            .........:..||.:      ..|.|    .|:::.|:.:         .|...|.:|....|.
Mosquito   510 ELRDREDRGSVHGSSA------RPGAAGLDGVPAAASRATS---------DRREGRDAGSNPAGP 559

  Fly   604 YNSTTAVNSALAKTIVTISAPPVAAASASSLHLGVGG-------RPSSVSTLTIASVPPTLSGSG 661
            ..:...  :|.::|..|:..||.....    ..|.|.       ||:.:..:..::....:.|:.
Mosquito   560 RQAHPL--AAPSQTAATLKLPPPCKCP----FFGEGAPGRQQYLRPAEIKIVKTSTDFGPMGGAA 618

  Fly   662 SPGGSVSGATTPLAPSLKALTPGPSNSSGHHVSFMPMTGMKRLRSSNASLGSPNGII-------- 718
            |.|.|:..:|..:: |...:|..|:.|....:|.:|.:.   |.|.:....:|.||.
Mosquito   619 SNGDSLVYSTISIS-SGSNVTTQPTRSISSSLSTLPASA---LASPSRKGSAPKGISVVTWDQRR 679

  Fly   719 -----STVAGADTTSAPSLIDASEDQVQMRN----QHRILE 750
                 |:..||.|:...:...||...|.:|.    :|..||
Mosquito   680 HQRRGSSFGGARTSLLLTPTKASPSSVSLRRSINLRHSALE 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	108/409 (26%)
		TM helix 2	143..169	CDD:320195	14/25 (56%)
		TM helix 3	182..212	CDD:320195	18/29 (62%)
		TM helix 4	224..246	CDD:320195	8/21 (38%)
		TM helix 5	266..295	CDD:320195	10/28 (36%)
		TM helix 6	297..442	CDD:320195	38/191 (20%)
		TM helix 7	453..478	CDD:320195	6/24 (25%)
5-HT2B	XP_061501050.1	None