DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and htr7b

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_021329876.1	Gene:	htr7b / 565304	ZFINID:	ZDB-GENE-091118-105	Length:	404	Species:	Danio rerio

Alignment Length:	449	Identity:	148/449 - (32%)
Similarity:	216/449 - (48%)	Gaps:	83/449 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 TELVL-NATTSATSATLSPAMVATGG--GGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVF 124
            ||:.| |.||......|:.|...:.|  |...|.:|||::.:      .|||:  |...:..||.
Zfish    16 TEIALFNGTTEFFPTALTTAEPRSNGSCGEQRTLDPDLTKTV------IVGLM--LSSITAVTVM 72

  Fly   125 GNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLD 189
            ||:||::||...:.|...:||.:.|||:||..|.:.||||:.:.::....|.||..:|:|:..:|
Zfish    73 GNTLVVIAVCVVKKLRQPSNYLLVSLAIADLSVAVAVMPFAIVTDLTGGVWLFGEVFCNIFIGMD 137

  Fly   190 VLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAARDG 254
            |:..||||:.|||||:|||..||.|.:||.|...:..|.:|..||:.|::|:.|....|   ...
Zfish   138 VMCCTASIMTLCVISVDRYLGITRPLTYPARQNGQLMAKMIVGVWLVSASITLPPFCGW---AHN 199

  Fly   255 EMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASGELQL 319
            ...|..|..::.:||.::|:.::||:|::||:|.|.:|::||   .||   |.|....:...:||
Zfish   200 VNTAGVCLISQDVGYTLYSTAVAFYIPMVVMLFMYYKIFKAA---RRS---GAKHNFTSLPPIQL 258

  Fly   320 TLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPL 384
            ........|.                    .|...|             |....:|.||  ...|
Zfish   259 ACPEPALATV--------------------DGFCMH-------------GMKNGATSEE--FSTL 288

  Fly   385 SALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVN----LLSGFC 445
            |.|.|    |.|         |..:.|.:|:|||.|||::||||..||||||:..    .:.|..
Zfish   289 SCLLN----RER---------RSASIFRREQKAATTLGVIMGVFSFCWLPFFLFTTARPFICGLL 340

  Fly   446 IEC----IEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRKIRRK 500
            ..|    :|.      ::.|||:.||.|||.|||.::||.|..:..|| .|..|.|.|:
Zfish   341 CNCAPVWLER------VLLWLGYTNSLMNPFIYAFFNRDLRSTYKDLL-RCRYRNINRR 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	66/171 (39%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	116/356 (33%)
htr7b	XP_021329876.1	7tmA_5-HT7	57..378	CDD:320452	128/391 (33%)
		TM helix 1	58..84	CDD:320452	12/27 (44%)
		TM helix 2	91..117	CDD:320452	12/25 (48%)
		TM helix 3	130..160	CDD:320452	16/29 (55%)
		TM helix 4	172..194	CDD:320452	7/21 (33%)
		TM helix 5	211..240	CDD:320452	11/28 (39%)
		TM helix 6	303..333	CDD:320452	17/29 (59%)
		TM helix 7	346..371	CDD:320452	12/30 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	2	1.960