DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and htr7a

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_021323081.1	Gene:	htr7a / 562111	ZFINID:	ZDB-GENE-130530-666	Length:	479	Species:	Danio rerio

Alignment Length:	495	Identity:	152/495 - (30%)
Similarity:	228/495 - (46%)	Gaps:	94/495 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 FNGLPTSTELVLNATTSATSATLSPAMVATGGGG---TTTPEPDLSEFLEALPNDRVG--LLAF- 114
            |||:..|..||......|..:  ....||.|.|.   ..:..|.|.|.:|.....|..  :|::
Zfish    38 FNGIMISEVLVPRLFKIAHES--GEVAVAAGSGSMDMKPSSSPILLEMMEVANGTRCAEQILSYG 100

  Fly   115 ----------LFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYE 169
                      |.:.:..|:.||.||:::|...:.|...:||.|.|||:||..|.|.||||.::.:
Zfish   101 EVEKVLIGGVLTMLTLITICGNMLVVISVCFVKKLRQPSNYLIVSLALADLSVALAVMPFVSITD 165

  Fly   170 VLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVW 234
            ::...|.||..:|:::.::||:..||||:.|||||:|||..||.|.:||:|......|.::.:||
Zfish   166 LIGGRWIFGKFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGWCMAKMVLSVW 230

  Fly   235 ICSSAISFPAIVWW-RAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVI 298
            :.|::|:.|.:..| :...|..:    |..::..||.::|:.::||:|:.||:..|.||:|||.:
Zfish   231 LLSASITLPPLFGWAQNVNDDRV----CLISQDFGYTIYSTAVAFYIPMTVMLVMYYRIFRAAKL 291

  Fly   299 QTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHH 363
            ......|                    .|..|.:|.:|........||.|.
Zfish   292 SAAKHTI--------------------TGFPRVEQEEVEEDEVEEDGGNGA-------------- 322

  Fly   364 HHNHGGGTTTSTPEEPD--DEPLSALHNNGLARH-----------RHMGKNFSLSRKLAKFAKEK 415
                         |||.  |....|:.   |.|.           |.:|:..|..|.::.|.:|:
Zfish   323 -------------EEPTGVDCVTVAIK---LQREVEECARLPRILRGVGRRCSDRRSISIFKREQ 371

  Fly   416 KAAKTLGIVMGVFIICWLPFFVVNLLSGF-C-IECIEHEEIVSAIVTWLGWINSCMNPVIYACWS 478
            |||.|||||:|.|.|||||||:::....| | .||......|...:.|||:.||.:||.|||.::
Zfish   372 KAAATLGIVVGAFTICWLPFFLLSTARPFICGTECSCIPLWVERTLLWLGYANSLINPFIYAFFN 436

  Fly   479 RDFRRAFVRLLCMCCPRKIRRKYQPTMRSKSQCHVAAAMV 518
            ||.|..: |.|..|..|.|.|:.     |.:..|.|..:|
Zfish   437 RDLRTTY-RSLLSCRYRNINRRL-----SAAGMHEALRLV 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	64/172 (37%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	117/364 (32%)
htr7a	XP_021323081.1	7tmA_5-HT7	105..443	CDD:320452	125/391 (32%)
		TM helix 1	106..132	CDD:320452	7/25 (28%)
		TM helix 2	139..165	CDD:320452	14/25 (56%)
		TM helix 3	178..208	CDD:320452	15/29 (52%)
		TM helix 4	220..242	CDD:320452	6/21 (29%)
		TM helix 5	259..288	CDD:320452	11/28 (39%)
		TM helix 6	368..398	CDD:320452	18/29 (62%)
		TM helix 7	411..436	CDD:320452	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	2	1.870