Protein Alignment Dop1R2 and hrh3

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001020689.1
• Gene: hrh3 / 561773
• ZFINID: ZDB-GENE-040724-204
• Length: 473
• Species: Danio rerio
• Alignment Length: 512
• Identity: 136/512 - (26%)
• Similarity: 218/512 - (42%)
• Gaps: 119/512 - (23%)

  Fly    58 GLPTSTELVL----------------NATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPN 106
            |:||:..|:.                |||:.|...|.               |...:::.:..|:
Zfish    13 GIPTAVSLMWKSGNHQSSNWSGMERENATSLADLDTF---------------ENRRAQYGQFSPS 62

  Fly   107 DRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVL 171
            ..:.|...:.|..||||.||:|||||.:.|:.|.|..|:|..:||:||.|||...:|....| ||
Zfish    63 TSIFLTVLMTLLVFATVLGNALVILAFVVEKSLRTQGNFFFLNLAIADFLVGGFCIPVYIPY-VL 126

  Fly   172 ENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGL-IAAVWI 235
            ...|..|...|.:|..:|.:..|||:.|:.:||.||:.::|...||..:..:.:.|.| :..||:
Zfish   127 TGEWRLGRGLCKLWLVVDYMLCTASVFNIVLISFDRFQSVTKAVSYRCQKGITKDAVLKMLCVWL 191

  Fly   236 CSSAISFPAIVWWRAARDGE-MPAYKC--TFTEHLGYLVFSSTISFYLPLLVMVFTYCRIY---- 293
            .:..:..|||:.|.....|. :|..:|  .|..:..:|:.:||:.|:.|.:.:.:....||
Zfish   192 AAFLLYGPAIISWEHITGGSVVPDGECYAEFYFNWYFLMTASTVEFFTPFISVTYFNLSIYINIR 256

  Fly   294 -RAAV-------IQTRSLKIGTKQVLMASGELQLTL-----------------RIHRGGTTRDQQ 333
             |.|:       ::.||.|:..    :.:|::|...                 |..|..:|.
Zfish   257 NRCAMREEQPTYVRLRSFKMKP----LGAGDVQRVFFVRPVEESRVADLASRSRCCRLASTA--- 314

  Fly   334 NQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSAL---------HN 389
             :||....|.|                  ........|....|....:|.:.|.         |:
Zfish   315 -KVSAAEFGNG------------------RQSKRRDSTLADLPPLQVEERILAASEAQFHYVDHS 360

  Fly   390 NGLARHR-----HMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCI-EC 448
            .|..|||     .:...|.|||       :||.||:|.:::.||.:||.|:.::.::...|. :|
Zfish   361 AGPHRHRPDMVASLANRFRLSR-------DKKVAKSLAVIVCVFGLCWAPYTLLMIIRAACHGQC 418

  Fly   449 IEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLC----MCCPRKIRRKY 501
            ::|  .:..|..||.||||.:||::|......|:|||.:|||    ...|:.|.:||
Zfish   419 VQH--YLYEISFWLLWINSSINPILYPLCHSSFKRAFSKLLCPSKTKIQPQNIDQKY 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	112/410 (27%)
		TM helix 2	143..169	CDD:320195	10/25 (40%)
		TM helix 3	182..212	CDD:320195	11/29 (38%)
		TM helix 4	224..246	CDD:320195	6/22 (27%)
		TM helix 5	266..295	CDD:320195	7/33 (21%)
		TM helix 6	297..442	CDD:320195	35/182 (19%)
		TM helix 7	453..478	CDD:320195	10/24 (42%)
hrh3	NP_001020689.1	7tmA_Histamine_H3R	65..453	CDD:320423	116/423 (27%)
		TM helix 1	66..92	CDD:320423	13/25 (52%)
		TM helix 2	99..126	CDD:320423	11/27 (41%)
		TM helix 3	137..167	CDD:320423	11/29 (38%)
		TM helix 4	182..200	CDD:320423	4/17 (24%)
		TM helix 5	225..255	CDD:320423	7/29 (24%)
		TM helix 6	381..411	CDD:320423	12/36 (33%)
		TM helix 7	421..446	CDD:320423	11/26 (42%)