Protein Alignment Dop1R2 and htr1b

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001122181.1
• Gene: htr1b / 561647
• ZFINID: ZDB-GENE-081022-141
• Length: 380
• Species: Danio rerio
• Alignment Length: 454
• Identity: 152/454 - (33%)
• Similarity: 219/454 - (48%)
• Gaps: 92/454 - (20%)

  Fly    55 YFNGLPTSTELVLNATTSATSATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFS 119
            ||...|...| |||::| .|:.||             ||:.|..:...|.   :|.|.:.|.|.:
Zfish     6 YFKPTPAHFE-VLNSST-GTNVTL-------------TPKTDEKQESFAF---QVTLSSVLGLIT 52

  Fly   120 FATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDI 184
            .||:..|:.||..:.:.|.|.|..|:.|.||||.|.||.::|||...||.|... |..|...|||
Zfish    53 LATILSNAFVIATISQSRKLQTPANFLIASLAVTDLLVSVLVMPICVLYTVTRE-WTLGQVICDI 116

  Fly   185 WRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWR 249
            |.|.|:...|||||:||||:|||||||||...|..:.|..||||::|..||.:.:||.|.. :||
Zfish   117 WLSSDITCCTASILHLCVIALDRYWAITDAVEYAKKRTQARAAGMVATAWIIAISISLPPF-FWR 180

  Fly   250 AARDGEMPAYKCTF-TEHLGYLVFSSTISFYLPLLVMVFTYCRIY---RAAVIQTRSLKIGTKQV 310
            ..:.||:..  |:. |:|:.|.::|:..:||:|.|:::..|.|||   |..:::....|.|.:
Zfish   181 QVKAGELTT--CSVNTDHIFYTIYSTFGAFYIPTLLLIALYGRIYVEARKRILKQSPKKPGKR-- 241

  Fly   311 LMASGELQL--------TLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNH 367
             :.|..|..        |..:|.|     :|:..|..|..|
Zfish   242 -LTSAHLSTNSPASVASTSPLHCG-----RQDLCSDSGSLG------------------------ 276

  Fly   368 GGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICW 432
                        .|..:....::.|           |.:|....|:|:||.|||||::|.:|:||
Zfish   277 ------------SDNQIRVTVSDSL-----------LEKKRISAARERKATKTLGIILGAYIVCW 318

  Fly   433 LPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCM-CCPR 495
            ||||:..||...|..|...|  :....||||::||.:||:||...:.||::||.:::.. ||.|
Zfish   319 LPFFIYTLLIPLCSSCFSPE--LFDFFTWLGYVNSLINPIIYTMSNDDFKKAFHKVISFRCCRR 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	127/374 (34%)
		TM helix 2	143..169	CDD:320195	13/25 (52%)
		TM helix 3	182..212	CDD:320195	21/29 (72%)
		TM helix 4	224..246	CDD:320195	10/21 (48%)
		TM helix 5	266..295	CDD:320195	11/31 (35%)
		TM helix 6	297..442	CDD:320195	33/152 (22%)
		TM helix 7	453..478	CDD:320195	10/24 (42%)
htr1b	NP_001122181.1	7tm_GPCRs	39..369	CDD:475119	133/393 (34%)
		TM helix 1	44..68	CDD:320455	8/23 (35%)
		TM helix 2	77..99	CDD:320455	12/21 (57%)
		TM helix 3	115..137	CDD:320455	14/21 (67%)
		TM helix 4	160..176	CDD:320455	6/15 (40%)
		TM helix 5	197..220	CDD:320455	6/22 (27%)
		TM helix 6	304..326	CDD:320455	13/21 (62%)
		TM helix 7	337..362	CDD:320455	11/26 (42%)