Protein Alignment Dop1R2 and htr2aa

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: XP_689300.7
• Gene: htr2aa / 560808
• ZFINID: ZDB-GENE-070912-500
• Length: 491
• Species: Danio rerio
• Alignment Length: 463
• Identity: 137/463 - (29%)
• Similarity: 213/463 - (46%)
• Gaps: 74/463 - (15%)

  Fly    37 SPSPSFFGSYNISEDVYFYFNGLPTSTE--LVLNATTSATSATLSPAMVATGGGGTTTPEPDLSE 99
            :|||..... |:..:.....|...|.||  |:.|.:....|:..:..:.:....|.||.|
Zfish    30 TPSPDIMLG-NVVHNSSIGCNRSWTDTEASLLPNLSMIGISSERTELLSSQRCNGETTKE----- 88

  Fly   100 FLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPF 164
              |.:..:...||  :.:....||.||.|||:||..||.|..|||||:.||||||.|:||:|||.
Zfish    89 --ELVRKNWAALL--ILVVVIVTVAGNILVIMAVNLERKLQNATNYFLMSLAVADMLLGLLVMPV 149

  Fly   165 SALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGL 229
            |.:..|...:|.|....|.:|..||||||||||::||.||||||.||.:|..:....:..||...
Zfish   150 SMVTIVYGYSWPFPASLCPMWIYLDVLFSTASIMHLCAISLDRYVAIRNPIRHNRSNSRSRARAK 214

  Fly   230 IAAVWICSSAISFPAIV-----WWRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVFTY 289
            |.|||..|:.||.|..|     ..:..:||     .|..|:: .:::..|.::|::||.:||.||
Zfish   215 ITAVWTISAGISMPIPVLGLRDHTKVFKDG-----SCLLTDN-SFVLIGSFVAFFVPLTIMVVTY 273

  Fly   290 CRIYRAAVIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLS 354
              ....:.:|:.:.....:.|........|||....|.:....:.::               .|.
Zfish   274 --FLTISALQSEATLCLDQLVPRPKWSTGLTLNFLPGPSFSPSEKKL---------------FLR 321

  Fly   355 HSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAK 419
            .|.|      ...|..:...||.              ..||           .:...:.|:||:|
Zfish   322 RSLS------REPGADSGVVTPP--------------FGRH-----------NMQSISNEQKASK 355

  Fly   420 TLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIV---TWLGWINSCMNPVIYACWSRDF 481
            .||:|..:|::.|.|||:.|:|:..|.....:..|::.::   .|:|:::|.:||::|..:::.:
Zfish   356 VLGVVFFLFVVMWCPFFITNVLAVVCEPNACNANIMNRLLNVFVWVGYLSSAVNPLVYTLFNKTY 420

  Fly   482 RRAFVRLL 489
            |.||.|.:
Zfish   421 RSAFARYI 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	116/370 (31%)
		TM helix 2	143..169	CDD:320195	17/25 (68%)
		TM helix 3	182..212	CDD:320195	21/29 (72%)
		TM helix 4	224..246	CDD:320195	10/21 (48%)
		TM helix 5	266..295	CDD:320195	8/28 (29%)
		TM helix 6	297..442	CDD:320195	27/144 (19%)
		TM helix 7	453..478	CDD:320195	7/27 (26%)
htr2aa	XP_689300.7	7tm_GPCRs	94..424	CDD:475119	118/385 (31%)
		TM helix 1	96..120	CDD:410628	11/25 (44%)
		TM helix 2	129..151	CDD:410628	15/21 (71%)
		TM helix 3	168..190	CDD:410628	14/21 (67%)
		TM helix 4	213..229	CDD:410628	7/15 (47%)
		TM helix 5	251..274	CDD:410628	8/25 (32%)
		TM helix 6	354..376	CDD:410628	9/21 (43%)
		TM helix 7	392..417	CDD:410628	6/24 (25%)