DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and adra1ab

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_021334987.1	Gene:	adra1ab / 557259	ZFINID:	ZDB-GENE-060503-384	Length:	431	Species:	Danio rerio

Alignment Length:	454	Identity:	160/454 - (35%)
Similarity:	225/454 - (49%)	Gaps:	86/454 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 VGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLEN 173
            :||:..|||. |. |.||.||||:|...|.|.:.|:|||.:||:||.|:..||:||||:.|.| .
Zfish    39 LGLVLVLFLI-FG-VMGNILVILSVACHRNLRSVTHYFIGNLAIADLLLSSVVLPFSAVSEAL-G 100

  Fly   174 TWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSS 238
            .|.||...|:.|.:||||..|||||:|||||:||..|::.|..||...|.:||...:||:|..|:
Zfish   101 RWVFGRHLCNAWTALDVLCCTASILSLCVISVDRCMAVSYPLQYPSFATGRRAMTAVAALWALSA 165

  Fly   239 AISFPAIVWWRAARDGEMPAYK--CTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTR 301
            |||...:..||.    .||..:  |...|..||.:||:..|||:||.|::..|||:|..|..:||
Zfish   166 AISVGPLFGWRE----PMPEDESVCRVNEDPGYAIFSAACSFYVPLAVILAMYCRVYVVARHKTR 226

  Fly   302 SLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHN 366
            ::  ...:......|..:|||||    .|..||
Zfish   227 AM--SKSRETNGLSEQGMTLRIH----CRKAQN-------------------------------- 253

  Fly   367 HGGGTTTSTPEEPDDEPLSALHNNGLARHRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIIC 431
                       :...|....|.|:          :|:..| |.||::|||||||||||:|.|::|
Zfish   254 -----------DTRKEDAMRLKNS----------HFAFMR-LLKFSREKKAAKTLGIVVGCFVLC 296

  Fly   432 WLPFFVVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCCPRK 496
            |||||:|..:|.. .......:.|..|..|||:.|||:||:||.|:|::|::||..:|...|..:
Zfish   297 WLPFFLVLPISSI-FPSHRPPDAVFKITFWLGYFNSCLNPIIYPCFSQEFKKAFQNVLHGRCLSR 360

  Fly   497 IRRKYQPTMRS-----KSQCHVAAAMV------AASTSFGYHSVNQIDR-----TLMXRQLSSC 544
            ..:.:.|...:     ||...:::...      .||:|....:.|..|.     :|. .|:|.|
Zfish   361 THQTWSPPANATQYMPKSPQGLSSGFTDSWRSDHASSSAVMLNENSYDEPDTSLSLKVHQVSIC 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	82/173 (47%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	132/350 (38%)
adra1ab	XP_021334987.1	7tm_GPCRs	48..349	CDD:333717	139/368 (38%)
		TM helix 2	72..94	CDD:320095	12/21 (57%)
		TM helix 3	110..132	CDD:320095	14/21 (67%)
		TM helix 4	155..171	CDD:320095	7/15 (47%)
		TM helix 5	192..215	CDD:320095	10/22 (45%)
		TM helix 6	280..305	CDD:320095	19/24 (79%)
		TM helix 7	317..342	CDD:320095	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2928
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001183
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X580
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.960