Protein Alignment Dop1R2 and drd4-rs

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001012638.3
• Gene: drd4-rs / 503566
• ZFINID: ZDB-GENE-051113-172
• Length: 418
• Species: Danio rerio
• Alignment Length: 422
• Identity: 130/422 - (30%)
• Similarity: 196/422 - (46%)
• Gaps: 93/422 - (22%)

  Fly   123 VFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRS 187
            :.||.||.|:|:.||.|.|||||||.||||||.|:.::|:|.....|.|...|......||...:
Zfish    33 ILGNVLVCLSVLTERSLKTATNYFIVSLAVADLLLAILVLPLYVYSEFLGGIWTLSMYICDALMT 97

  Fly   188 LDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAAR 252
            :||:..||||||||.||:|||.|:..|..|.......|...||.|.|:.|..::.|.|...
Zfish    98 MDVMLCTASILNLCAISVDRYIAVVVPLKYNRNQFSVRQLALITATWVLSLGVASPVIFGL---- 158

  Fly   253 DGEMP---AYKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLM-- 312
             .::|   .:.|...:: .::|:||..||::|..||:|.|..::|.    .:....|..:..:
Zfish   159 -NQVPNRNPHVCKLEDN-QFVVYSSVCSFFVPCPVMLFLYYWMFRG----LKRWSSGRNRSHLRR 217

  Fly   313 -ASGELQLTLRI-----HRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGT 371
             ..|...|:||:     ...|..|::...:...|            ||.:              :
Zfish   218 PPRGRRSLSLRLGAALQKEKGRAREKVVYLMPAG------------LSPT--------------S 256

  Fly   372 TTSTPEEP-----------DD-----------EPLSAL-------------------HNNGLAR- 394
            .|:||..|           ||           :|::..                   ..||:.:
Zfish   257 LTATPTTPISSTSPVTLTTDDLAEGQMPGAESDPMTTQMDSVSDAENPERATEDDSGRENGVGKN 321

  Fly   395 HR-HMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAI 458
            || |.|:..|.|.:::  .:|:||.|.|.:|:|||:.||.|||||::....|..|.....::| :
Zfish   322 HRPHTGRRHSKSNRVS--GRERKAMKVLPVVVGVFLACWTPFFVVHVTKALCESCDIGPTLIS-V 383

  Fly   459 VTWLGWINSCMNPVIYACWSRDFRRAFVRLLC 490
            |||||::||.:||:||..::.:||..|.:|||
Zfish   384 VTWLGYVNSAVNPIIYTAFNVEFRNVFHKLLC 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	126/415 (30%)
		TM helix 2	143..169	CDD:320195	14/25 (56%)
		TM helix 3	182..212	CDD:320195	18/29 (62%)
		TM helix 4	224..246	CDD:320195	7/21 (33%)
		TM helix 5	266..295	CDD:320195	10/28 (36%)
		TM helix 6	297..442	CDD:320195	41/195 (21%)
		TM helix 7	453..478	CDD:320195	12/24 (50%)
drd4-rs	NP_001012638.3	7tmA_D4_dopamine_R	19..410	CDD:320434	126/415 (30%)
		TM helix 1	20..46	CDD:320434	6/12 (50%)
		TM helix 2	53..79	CDD:320434	14/25 (56%)
		TM helix 3	92..122	CDD:320434	18/29 (62%)
		TM helix 4	134..157	CDD:320434	8/22 (36%)
		TM helix 5	173..202	CDD:320434	10/29 (34%)
		TM helix 6	338..368	CDD:320434	16/29 (55%)
		TM helix 7	378..403	CDD:320434	12/25 (48%)