Protein Alignment Dop1R2 and drd4b

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001012636.1
• Gene: drd4b / 503565
• ZFINID: ZDB-GENE-070508-3
• Length: 382
• Species: Danio rerio
• Alignment Length: 447
• Identity: 127/447 - (28%)
• Similarity: 197/447 - (44%)
• Gaps: 99/447 - (22%)

  Fly    75 SATLSPAMVATGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYL 139
            |:||.||:                 |...:|     .|.|..|.....:.||.||.|:|.:|:.|
Zfish     6 SSTLQPAL-----------------FTYNVP-----ALVFGILLIIVIICGNVLVCLSVYKEKAL 48

  Fly   140 HTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVIS 204
            .|.|||||.||||||.::.::|:|.....|.....|......||...::||:..||||.|||.||
Zfish    49 KTTTNYFIVSLAVADLMLAVLVLPLFVYAEFQGGVWSLNVSVCDGLMTMDVMLCTASIFNLCAIS 113

  Fly   205 LDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWR--AARDGEMPAYKCTFTEHL 267
            :||:.|::.|.:|..:....|...|::|.|:.:.|::.|.|....  ..||   |: :|...::
Zfish   114 VDRFIAVSIPLNYNRKHVDYRQIILLSATWLLALAVASPVIFGINNVPQRD---PS-ECKLEDN- 173

  Fly   268 GYLVFSSTISFYLPLLVMVFTYCRIY--------------RAAVIQTRSLK-IGTKQVLMASGEL 317
            .|:|:||..||::|..:|:..|..::              |.::...|||: ......|...|.|
Zfish   174 NYVVYSSVCSFFIPCPIMLMLYFGMFHGLRKWEETRKAKLRNSIQACRSLQHAAVAAALPPLGAL 238

  Fly   318 QLTL-RIHRGGTTRDQQNQVSGGGGGGGGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDD 381
            ..:| |:    ..||                                       ...|:.||.||
Zfish   239 PASLPRV----IERD---------------------------------------LAQSSLEELDD 260

  Fly   382 --EPLSAL----HNNGLARHRHMGKNFSLSRKLAKFAK----EKKAAKTLGIVMGVFIICWLPFF 436
              :|:...    .|:.:....:....:....:..|.||    |:||.:.|.:|:|||:.||.|||
Zfish   261 FTQPVCPFPPEYKNSTIQTVAYSDIQYGQKTQRKKRAKINGRERKAMRVLPVVVGVFLFCWTPFF 325

  Fly   437 VVNLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMCC 493
            ||:.....|..|....:::|. |||||::||.:||:||..::.:||:.|...:..||
Zfish   326 VVHTTRALCESCHISSDLMST-VTWLGYVNSALNPIIYTVFNTEFRKFFRGFVPRCC 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	114/390 (29%)
		TM helix 2	143..169	CDD:320195	13/25 (52%)
		TM helix 3	182..212	CDD:320195	16/29 (55%)
		TM helix 4	224..246	CDD:320195	6/21 (29%)
		TM helix 5	266..295	CDD:320195	9/42 (21%)
		TM helix 6	297..442	CDD:320195	35/156 (22%)
		TM helix 7	453..478	CDD:320195	12/24 (50%)
drd4b	NP_001012636.1	7tmA_D4_dopamine_R	20..373	CDD:320434	117/401 (29%)
		TM helix 1	20..45	CDD:320434	9/24 (38%)
		TM helix 2	52..78	CDD:320434	13/25 (52%)
		TM helix 3	91..121	CDD:320434	16/29 (55%)
		TM helix 4	133..156	CDD:320434	7/22 (32%)
		TM helix 5	172..201	CDD:320434	9/29 (31%)
		TM helix 6	301..331	CDD:320434	15/29 (52%)
		TM helix 7	341..366	CDD:320434	12/25 (48%)