DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R2 and Oamb

DIOPT Version :9

Sequence 1:	NP_001263072.1	Gene:	Dop1R2 / 43484	FlyBaseID:	FBgn0266137	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001262774.1	Gene:	Oamb / 43982	FlyBaseID:	FBgn0024944	Length:	751	Species:	Drosophila melanogaster

Alignment Length:	807	Identity:	215/807 - (26%)
Similarity:	305/807 - (37%)	Gaps:	290/807 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLVGLVVMPFSALYEVLENTWF 176
            ||.|...:...:.||.|||.||.....|.:.||:||.:|||||.||||.|:||||.:||.: .|.
  Fly    24 LAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFK-VWI 87

  Fly   177 FGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMTVKRAAGLIAAVWICSSAIS 241
            ||..||.||.::||...||||||||.||||||.|:|.|.:||..|:.|:|..|||.:|:.|..|.
  Fly    88 FGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFIC 152

  Fly   242 FPAIVWWR------------------------AARDGEM--------------PA---------- 258
            ||.:|.|:                        ::.||::              |:
  Fly   153 FPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGNAY 217

  Fly   259 ----------------------------------------------------------------- 258

  Fly   218 NPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTISGS 282

  Fly   259 --YKCTFTEHLGYLVFSSTISFYLPLLVMVFTYCRIYRAAVIQTRSLKIGTKQVLMASG------ 315
              :||..|...||:::|:..|||:|:.||:|.|.|||||||..||::..|.|....:.|
  Fly   283 CPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIGSRFE 347

  Fly   316 ELQLTLRIHRGGTTRDQQNQVSGGGGGGGGGGGGGGS---LSHSHSHSHHHHH------------ 365
            |.:||||||||..:..|.:..|.|.........|..|   ||...:...|||.
  Fly   348 EQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSYPSSE 412

  Fly   366 ------NHGGGTTTSTPEEPDDEPLSALHNNG--------------------------------- 391
                  .||   ............|.|:|.||
  Fly   413 NISELAGHG---DVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKGLP 474

  Fly   392 -LAR-----------------HRHMGKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVV 438
             |||                 ::.||:. ::..::.:|..|.||||||.|::|:||.||.|||.:
  Fly   475 ELARRQSNTSEAGGSGHSRPANKKMGRR-NIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTM 538

  Fly   439 NLLSGFCIECIEHEEIVSAIVTWLGWINSCMNPVIYACWSRDFRRAFVRLLCMC-CPRK-IRRKY 501
            .::..||.:|:  :.::.:::.|||:.||.:||:|||.:|:|||.||.|::|.| |.|: :..|
  Fly   539 YIIRPFCQDCV--DPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSRQSVSLK- 600

  Fly   502 QPTMRSKSQCHVAAAMVAASTSFGYHSVNQIDRTLMXRQLSSCSTCSGGSNCGGSRSAHHQHHSS 566
                .|:....::|..:.|.|.    |:                |.|..::..|..|  ..|||.
  Fly   601 ----SSRRGSDMSAIRIRARTP----SI----------------TPSAAAHSFGDES--ELHHSE 639

  Fly   567 GTATPSSSQRSCTRCQSFHRHHHRSRRRSSGMQMRGDYNSTTAVNSALAKTIVTISAPPVAAASA 631
            .:..|        | :||                 |..:|:.:....|.||.:.:....:.
  Fly   640 MSNDP--------RXRSF-----------------GPSSSSQSSLGGLRKTSLKVPVYEIC---- 675

  Fly   632 SSLHLGVGGRPSSVSTLTIASVPPTLSGSGSPGGSVSGATTPLAPSLKALTPGPSNSSGHHVSFM 696
                     .|..:.|...:.|..|..||.|  .||:|......|....| |
  Fly   676 ---------HPLVMETACYSYVEATSDGSAS--CSVAGGNGGSVPKRTQLXP------------- 716

  Fly   697 PMTGMKRLRSSNASLGSPNGIISTVAG 723
                    |...|..|:..|:|...||
  Fly   717 --------RELMALRGTRTGVIPLPAG 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tm_4	123..>295	CDD:304433	89/286 (31%)
Dop1R2	NP_001263072.1	7tm_1	125..474	CDD:278431	156/541 (29%)
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	65/125 (52%)
Oamb	NP_001262774.1	7tm_1	37..>181	CDD:278431	69/144 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468036
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62845at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.850