Protein Alignment Dop1R2 and 5-HT7

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_524599.1
• Gene: 5-HT7 / 43669
• FlyBaseID: FBgn0004573
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 485
• Identity: 164/485 - (33%)
• Similarity: 229/485 - (47%)
• Gaps: 84/485 - (17%)

  Fly    37 SPSPSFFGSYNISEDVYFYFNGLPTSTELVLNATTSATSATLSPAMVATGGGGTT-TPEPDLSEF 100
            |.|.|..|||.::.         ..|:.:.:.:....||:.|       |...|| .|..|....
  Fly    98 SGSGSGSGSYGLAS---------MNSSPIAIVSYQGITSSNL-------GDSNTTLVPLSDTPLL 146

  Fly   101 LEAL--------PNDRVGLLAFLFLFSFATVFGNSLVILAVIRERYLHTATNYFITSLAVADCLV 157
            ||..        |...:.:...|.:....||.||.||.:||...|.|....||.:.|||::|..|
  Fly   147 LEEFAAGEFVLPPLTSIFVSIVLLIVILGTVVGNVLVCIAVCMVRKLRRPCNYLLVSLALSDLCV 211

  Fly   158 GLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDRYWAITDPFSYPMRMT 222
            .|:|||.:.||||||. |.||...||||.|.|||..||||||||.||:|||.|||.|..|.::.|
  Fly   212 ALLVMPMALLYEVLEK-WNFGPLLCDIWVSFDVLCCTASILNLCAISVDRYLAITKPLEYGVKRT 275

  Fly   223 VKRAAGLIAAVWICSSAISFPAIVWWRAARDGEMPAYKCTFTEHLGYLVFSSTISFYLPLLVMVF 287
            .:|....:..||:.::.||.|.::......:.|.....||..::..|.::::..|||:||.||:|
  Fly   276 PRRMMLCVGIVWLAAACISLPPLLILGNEHEDEEGQPICTVCQNFAYQIYATLGSFYIPLSVMLF 340

  Fly   288 TYCRIYRAA---VIQTRSLKIGTKQVLMASGELQLTLRIHRGGTTRDQQNQVSGGGGGG------ 343
            .|.:|:|||   |::.:..:...:|.|..:|..........|.|      :::..|.|.
  Fly   341 VYYQIFRAARRIVLEEKRAQTHLQQALNGTGSPSAPQAPPLGHT------ELASSGNGQRHSSVG 399

  Fly   344 ---------GGGGGGGGSLSHSHSHSHHHHHNHGGGTTTSTPEEPDDEPLSALHNNGLARHRHMG 399
                     ||...|||:|:         .|..|||.:.||               ||....|..
  Fly   400 NTSLTYSTCGGLSSGGGALA---------GHGSGGGVSGST---------------GLLGSPHHK 440

  Fly   400 K-NFSLSRKLAKFAKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAIVTWLG 463
            | .|.|       ||||||:.||||:|..|.:||||||::.|:..|  |.:.....:|::..|||
  Fly   441 KLRFQL-------AKEKKASTTLGIIMSAFTVCWLPFFILALIRPF--ETMHVPASLSSLFLWLG 496

  Fly   464 WINSCMNPVIYACWSRDFRRAFVRLLCMCC 493
            :.||.:||:|||..:||||:.|..:|...|
  Fly   497 YANSLLNPIIYATLNRDFRKPFQEILYFRC 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	142/381 (37%)
		TM helix 2	143..169	CDD:320195	12/25 (48%)
		TM helix 3	182..212	CDD:320195	22/29 (76%)
		TM helix 4	224..246	CDD:320195	6/21 (29%)
		TM helix 5	266..295	CDD:320195	11/28 (39%)
		TM helix 6	297..442	CDD:320195	45/160 (28%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)
5-HT7	NP_524599.1	7tmA_5-HT7	163..518	CDD:320452	143/394 (36%)
		TM helix 1	164..190	CDD:320452	9/25 (36%)
		TM helix 2	197..223	CDD:320452	12/25 (48%)
		TM helix 3	235..265	CDD:320452	22/29 (76%)
		TM helix 4	277..299	CDD:320452	6/21 (29%)
		TM helix 5	319..348	CDD:320452	11/28 (39%)
		TM helix 6	447..477	CDD:320452	19/29 (66%)
		TM helix 7	486..511	CDD:320452	11/24 (46%)