Protein Alignment Dop1R2 and Octalpha2R

DIOPT Version :10

• Sequence 1: NP_001263072.1
• Gene: Dop1R2 / 43484
• FlyBaseID: FBgn0266137
• Length: 807
• Species: Drosophila melanogaster
• Sequence 2: NP_001262715.1
• Gene: Octalpha2R / 42258
• FlyBaseID: FBgn0038653
• Length: 740
• Species: Drosophila melanogaster
• Alignment Length: 730
• Identity: 193/730 - (26%)
• Similarity: 274/730 - (37%)
• Gaps: 253/730 - (34%)

  Fly    24 LLRVDGLNQTQTRSPSPSFFGSYNISEDVYFYFNGLPTSTELVLNA----TTSATSATLSPAMVA 84
            ||.|||    |...|..|  |..|:: |..|:.||...::.|.|.|    .:||:.||
  Fly    38 LLSVDG----QLTLPPGS--GYVNVN-DTIFFLNGSFYNSSLQLAAGFYNQSSASGAT------- 88

  Fly    85 TGGGGTTTPEPDLSEFLEALPNDRVGLLAFLFLFSFAT-------VFGNSLVILAVIRERYLHTA 142
              .|..|.|......:....|:...  |..:.:.|...       |.||.|||:|:..|:.|...
  Fly    89 --SGNLTNPNHTEVHWDGRYPSGYT--LTHIVIASIIVTILMIIIVVGNMLVIIAIATEKSLKNI 149

  Fly   143 TNYFITSLAVADCLVGLVVMPFSALYEVLENTWFFGTDWCDIWRSLDVLFSTASILNLCVISLDR 207
            .|:||.||||||..:||::||||...|:: ..|.||:.||||..::|||..||||:|||:|||||
  Fly   150 QNWFIASLAVADFFLGLIIMPFSLANELM-GYWIFGSWWCDIHSAMDVLLCTASIMNLCLISLDR 213

  Fly   208 YWAITDPFSYPMRMTVKRAAGLIAAVWICSSAISFPAIVWWRAAR-DGEMPAYKCTFTEHLGYLV 271
            ||:||....|....|..|||.:|.||||.|:.|..|.::.|:... :|.:|  ||..:|.:||::
  Fly   214 YWSITKAVDYLKSRTPARAAVMITAVWIMSALICIPPLLGWKVKMPEGPLP--KCELSEDIGYVL 276

  Fly   272 FSSTISFYLPLLVMVFTYCRIYRAAVIQTR-------------------SLKIGTKQVLMASGEL 317
            :|:..|||:|..:|||.|.|||.||..:.|                   :.|.||..:..:||..
  Fly   277 YSALGSFYIPSCIMVFVYIRIYFAAKARARRGIKKHPRKTNNEQVTSFTTAKKGTIPMPSSSGVS 341

  Fly   318 QLTLRIHR---------------------------------------------------GGTTRD 331
            .|.|...|                                                   .|...:
  Fly   342 ALQLHQQRQIATIETPPNSASLPMQIPTVTMDLASDISTSEAGELEAVAAQTVLAYANPNGAGTN 406

  Fly   332 QQNQVSGGGGGGGGGG-----------------GGGG-------SLSHSHSHSHHHHHN------ 366
            ....||.|.||.|..|                 |..|       |:..:.|.:..:::|
  Fly   407 SVTVVSSGNGGPGASGVPPSSPKETLQVSTIATGRVGLNVPVPPSMGSNSSINVLNNNNGTVAMD 471

  Fly   367 -------HGGGTTTSTP------------------------------------------------ 376
                   .|.|:..:||
  Fly   472 GGATAAGGGNGSAVATPGGLQQTGGNELRVSPIAGRCRALSVGVDTDMVSEFDPSSSDSGVVSRC 536

  Fly   377 ---------------------EEPDDEPLSALHN---NGLARHRHMGKNFSLSRKLAKF------ 411
                                 ::..:|..:|..|   :|:|......:.....:::.|.
  Fly   537 AVVKPLKFRLCQPIFGRKSSNQQRRNEAKAAAKNQQSSGVASKNQQQQQQQQQQQVVKSELEPAI 601

  Fly   412 ------------------AKEKKAAKTLGIVMGVFIICWLPFFVVNLLSGFCIECIEHEEIVSAI 458
                              .|||:|...||::||.||.||||||.:.:|...|.......|...|:
  Fly   602 PKTPKPRDPEKEKRRIARKKEKRATLILGLIMGSFIACWLPFFFLYILVPACSSHCNIPESAFAV 666

  Fly   459 VTWLGWINSCMNPVIYACWSRDFRRAFVRLL---CM---CCPRKIRRKYQPTMRSKSQCHVAAAM 517
            ..|||::||.:||.||..:::||||||.|:|   |:   ||.|.:....:.          |...
  Fly   667 AFWLGYMNSALNPAIYTIFNKDFRRAFRRILFKXCLAYVCCYRCVYASIEK----------ATER 721

  Fly   518 VAASTSFGY-HSVNQ 531
            ...||..|| |.:.|
  Fly   722 AMGSTPMGYGHGMYQ 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R2	NP_001263072.1	7tmA_Dop1R2-like	122..485	CDD:320195	151/573 (26%)
		TM helix 2	143..169	CDD:320195	15/25 (60%)
		TM helix 3	182..212	CDD:320195	20/29 (69%)
		TM helix 4	224..246	CDD:320195	11/21 (52%)
		TM helix 5	266..295	CDD:320195	14/28 (50%)
		TM helix 6	297..442	CDD:320195	48/347 (14%)
		TM helix 7	453..478	CDD:320195	11/24 (46%)
Octalpha2R	NP_001262715.1	7tmA_alpha2_AR	132..>307	CDD:320187	85/177 (48%)
		TM helix 2	150..176	CDD:320187	15/25 (60%)
		TM helix 3	188..218	CDD:320187	20/29 (69%)
		TM helix 4	230..253	CDD:320187	11/22 (50%)
		TM helix 5	271..300	CDD:320187	14/28 (50%)
		7tm_GPCRs	<616..693	CDD:475119	33/76 (43%)
		TM helix 6	626..648	CDD:410628	12/21 (57%)
		TM helix 7	661..686	CDD:410628	11/24 (46%)